Version 5.4
Homo sapiens Protein: BPHL
Summary
InnateDB Protein IDBP-57416.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BPHL
Protein Name biphenyl hydrolase-like (serine hydrolase)
Synonyms BPH-RP; MCNAA; VACVASE;
Species Homo sapiens
Ensembl Protein ENSP00000369734
InnateDB Gene IDBG-57412 (BPHL)
Protein Structure
UniProt Annotation
Function Serine hydrolase that catalyzes the hydrolytic activation of amino acid ester prodrugs of nucleoside analogs such as valacyclovir and valganciclovir. Activates valacyclovir to acyclovir. May play a role in detoxification processes. It is a specific alpha-amino acid ester hydrolase that prefers small, hydrophobic, and aromatic side chains and does not have a stringent requirement for the leaving group other than preferring a primary alcohol. {ECO:0000269PubMed:18256025}.
Subcellular Localization
Disease Associations
Tissue Specificity Expressed at high levels in liver and kidney and lower levels in heart, intestine and skeletal muscle. {ECO:0000269PubMed:7759552}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0016787 hydrolase activity
Biological Process
GO:0006520 cellular amino acid metabolic process
GO:0009636 response to toxic substance
Cellular Component
GO:0005739 mitochondrion
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR000073 Alpha/beta hydrolase fold-1
IPR029058 Alpha/Beta hydrolase fold
PFAM PF00561
PRINTS PR00111
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q86WA6
PhosphoSite PhosphoSite-Q86WA6
TrEMBL A0A024QZY0
UniProt Splice Variant
Entrez Gene 670
UniGene Hs.733339
RefSeq
HUGO HGNC:1094
OMIM 603156
CCDS
HPRD 04403
IMGT
EMBL AJ617684 AL031963 BC106901 CH471087 X57653 X81372
GenPept AAI06902 CAA40859 CAA57137 CAD70626 CAD70627 CAE85120 EAW55122 EAW55123

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca