InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SH2B3

Summary

InnateDB Protein

IDBP-57460.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SH2B3

Protein Name

SH2B adaptor protein 3

Synonyms

IDDM20; LNK;

Species

Homo sapiens

Ensembl Protein

ENSP00000345492

InnateDB Gene

IDBG-57458 (SH2B3)

Protein Structure

UniProt Annotation

Function

Links T-cell receptor activation signal to phospholipase C-gamma-1, GRB2 and phosphatidylinositol 3-kinase. {ECO:0000250}.

Subcellular Localization

Disease Associations

Celiac disease 13 (CELIAC13) [MIM:612011]: A multifactorial, chronic disorder of the small intestine caused by intolerance to gluten. It is characterized by immune-mediated enteropathy associated with failed intestinal absorption, and malnutrition. In predisposed individuals, the ingestion of gluten- containing food such as wheat and rye induces a flat jejunal mucosa with infiltration of lymphocytes. {ECO:0000269PubMed:18311140}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.Diabetes mellitus, insulin-dependent (IDDM) [MIM:222100]: A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical features are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. {ECO:0000269PubMed:17554260}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Tissue Specificity

Preferentially expressed by lymphoid cell lines.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0032403	protein complex binding
GO:0042301	phosphate ion binding

Biological Process

GO:0007596	blood coagulation
GO:0030097	hemopoiesis
GO:0030154	cell differentiation
GO:0035162	embryonic hemopoiesis
GO:0035556	intracellular signal transduction