InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SH2B3

Summary

InnateDB Gene

IDBG-57458.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SH2B3

Gene Name

SH2B adaptor protein 3

Synonyms

IDDM20; LNK

Species

Homo sapiens

Ensembl Gene

ENSG00000111252

Encoded Proteins

IDBP-57460

SH2B adaptor protein 3

IDBP-812316

SH2B adaptor protein 3

IDBP-601063

SH2B adaptor protein 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the SH2B adaptor family of proteins, which are involved in a range of signaling activities by growth factor and cytokine receptors. The encoded protein is a key negative regulator of cytokine signaling and plays a critical role in hematopoiesis. Mutations in this gene have been associated with susceptibility to celiac disease type 13 and susceptibility to insulin-dependent diabetes mellitus.[provided by RefSeq, May 2010]
This gene encodes a member of the SH2B adaptor family of proteins, which are involved in a range of signaling activities by growth factor and cytokine receptors. The encoded protein is a key negative regulator of cytokine signaling and plays a critical role in hematopoiesis. Mutations in this gene have been associated with susceptibility to celiac disease type 13 and susceptibility to insulin-dependent diabetes mellitus. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:111405948-111451623

Strand

Forward strand

Band

q24.12

Transcripts

ENST00000341259	ENSP00000345492
ENST00000550925	ENSP00000473529
ENST00000538307	ENSP00000440597

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0032403	protein complex binding
GO:0042301	phosphate ion binding

Biological Process

GO:0007596	blood coagulation
GO:0030097	hemopoiesis
GO:0030154	cell differentiation
GO:0035162	embryonic hemopoiesis
GO:0035556	intracellular signal transduction