InnateDB Protein
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IDBP-57905.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SNRPD2
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Protein Name
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small nuclear ribonucleoprotein D2 polypeptide 16.5kDa
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Synonyms
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Sm-D2; SMD2; SNRPD1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000342374
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InnateDB Gene
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IDBG-57903 (SNRPD2)
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Protein Structure
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Function |
Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in an heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. {ECO:0000269PubMed:18984161, ECO:0000269PubMed:23333303}.
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Subcellular Localization |
Cytoplasm, cytosol {ECO:0000269PubMed:18984161}. Nucleus {ECO:0000269PubMed:18984161}. Note=SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 122 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
122
[view]
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Protein-Protein |
118
[view]
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Protein-DNA |
4
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001163
Ribonucleoprotein LSM domain
IPR006649
Ribonucleoprotein LSM domain, eukaryotic/archaea-type
IPR010920
Like-Sm (LSM) domain
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PFAM |
PF01423
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PRINTS |
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PIRSF |
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SMART |
SM00651
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TIGRFAMs |
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Modification |
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SwissProt |
P62316
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PhosphoSite |
PhosphoSite-P62316
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TrEMBL |
K7EJB5
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UniProt Splice Variant |
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Entrez Gene |
6633
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UniGene |
Hs.737619
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RefSeq |
NP_004588
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HUGO |
HGNC:11159
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OMIM |
601061
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CCDS |
CCDS33053
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HPRD |
03038
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IMGT |
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EMBL |
AC007191
AK291912
BC000486
BC001930
BU531743
CH471126
U15008
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GenPept |
AAC13776
AAD22673
AAH00486
AAH01930
BAF84601
EAW57373
EAW57374
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