InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DBR1

Summary

InnateDB Protein

IDBP-58194.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DBR1

Protein Name

debranching enzyme homolog 1 (S. cerevisiae)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000260803

InnateDB Gene

IDBG-58192 (DBR1)

Protein Structure

UniProt Annotation

Function

Cleaves the 2'-5' phosphodiester linkage at the branch point of lariat intron pre-mRNAs after splicing and converts them into linear molecules that are subsequently degraded. It thereby facilitates ribonucleotide turnover. It may also participate in retrovirus replication via an RNA lariat intermediate in cDNA synthesis. {ECO:0000269PubMed:10982890, ECO:0000269PubMed:16232320}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	4 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008419	RNA lariat debranching enzyme activity
GO:0016787	hydrolase activity
GO:0016788	hydrolase activity, acting on ester bonds
GO:0044822	poly(A) RNA binding
GO:0046872	metal ion binding

Biological Process

GO:0000375	RNA splicing, via transesterification reactions
GO:0000398	mRNA splicing, via spliceosome
GO:0006397	mRNA processing
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

InterPro

IPR004843 Calcineurin-like phosphoesterase domain, apaH type
IPR007708 Lariat debranching enzyme, C-terminal
IPR029052 Metallo-dependent phosphatase-like

PFAM

PF00149
PF05011

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9UK59

PhosphoSite