Version 5.4
Homo sapiens Gene: DBR1
Summary
InnateDB Gene IDBG-58192.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DBR1
Gene Name debranching enzyme homolog 1 (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000138231
Encoded Proteins
IDBP-58194
debranching enzyme homolog 1 (S. cerevisiae)
IDBP-481841
debranching enzyme homolog 1 (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is an RNA lariat debranching enzyme that hydrolyzes 2'-5' prime branched phosphodiester bonds. The encoded protein specifically targets the bonds at the branch point of excised lariat intron RNA, converting them to linear molecules that are then degraded. This protein may also be involved in retroviral replication. [provided by RefSeq, Nov 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:138161012-138174949
Strand Reverse strand
Band q22.3
Transcripts
ENST00000260803 ENSP00000260803
ENST00000460271
ENST00000477557 ENSP00000417262
ENST00000463982
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 4 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008419 RNA lariat debranching enzyme activity
GO:0016787 hydrolase activity
GO:0016788 hydrolase activity, acting on ester bonds
GO:0044822 poly(A) RNA binding
GO:0046872 metal ion binding
Biological Process
GO:0000375 RNA splicing, via transesterification reactions
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008152 metabolic process
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032469
View Gene Order
ENSBTAG00000019949
Not yet available
Cross-References
SwissProt Q9UK59
TrEMBL F5GWV2 F8WAY1
UniProt Splice Variant
Entrez Gene 51163
UniGene Hs.477700 Hs.630625
RefSeq NM_016216
HUGO HGNC:15594
OMIM 607024
CCDS CCDS33863
HPRD
IMGT
EMBL AC023049 AC068777 AF180919 AK000116 BC009472
GenPept AAD53327 AAH09472 BAA90954
RNA Seq Atlas 51163

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca