Version 5.4
Homo sapiens Protein: IRF2BP1
Summary
InnateDB Protein IDBP-58311.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IRF2BP1
Protein Name interferon regulatory factor 2 binding protein 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000307265
InnateDB Gene IDBG-58309 (IRF2BP1)
Protein Structure
UniProt Annotation
Function Acts as a transcriptional corepressor in a IRF2- dependent manner; this repression is not mediated by histone deacetylase activities. May act as an E3 ligase towards JDP2, enhancing its polyubiquitination. Represses ATF2-dependent transcriptional activation. {ECO:0000269PubMed:12799427, ECO:0000269PubMed:18671972}.
Subcellular Localization Nucleus {ECO:0000269PubMed:12799427}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
Experimentally validated
Total 21 [view]
Protein-Protein 21 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0016874 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR022750 Interferon regulatory factor 2-binding protein 1 & 2, zinc finger
PFAM PF11261
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8IU81
PhosphoSite PhosphoSite-Q8IU81
TrEMBL
UniProt Splice Variant
Entrez Gene 26145
UniGene Hs.515477
RefSeq NP_056464
HUGO HGNC:21728
OMIM 615331
CCDS CCDS12678
HPRD 17159
IMGT
EMBL AK223622 AL080159 AY278022 BC005834 BC038222 BC039002 BC078181 CH471126
GenPept AAH05834 AAH38222 AAH39002 AAH78181 AAP78943 BAD97342 CAB45750 EAW57396

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca