InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MED25

Summary

InnateDB Protein

IDBP-583119.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MED25

Protein Name

mediator complex subunit 25

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000437496

InnateDB Gene

IDBG-63568 (MED25)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 62 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	62 [view]
Protein-Protein	61 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0042974	retinoic acid receptor binding
GO:0046965	retinoid X receptor binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0008219	cell death
GO:0010467	gene expression
GO:0035563	positive regulation of chromatin binding
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048147	negative regulation of fibroblast proliferation
GO:0071158	positive regulation of cell cycle arrest
GO:2001178	positive regulation of mediator complex assembly

Cellular Component

GO:0005654

nucleoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR021394 Mediator complex, subunit Med25, PTOV activation and synapsin 2
IPR021397 Mediator complex, subunit Med25, synapsin 1
IPR021406 Mediator complex, subunit Med25, NR box
IPR021419 Mediator complex, subunit Med25, von Willebrand factor type A

PFAM

PF11232
PF11235
PF11244
PF11265

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q71SY5

PhosphoSite