Version 5.4
Homo sapiens Protein: INTS4
Summary
InnateDB Protein IDBP-583448.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol INTS4
Protein Name integrator complex subunit 4
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000434466
InnateDB Gene IDBG-65759 (INTS4)
Protein Structure
UniProt Annotation
Function Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes.
Subcellular Localization Nucleus {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
Experimentally validated
Total 13 [view]
Protein-Protein 12 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
Biological Process
GO:0016180 snRNA processing
Cellular Component
GO:0032039 integrator complex
Protein Structure and Domains
PDB ID
InterPro IPR000357 HEAT
IPR016024 Armadillo-type fold
PFAM PF02985
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96HW7
PhosphoSite PhosphoSite-Q96HW7
TrEMBL
UniProt Splice Variant
Entrez Gene 92105
UniGene Hs.601988
RefSeq NP_291025
HUGO HGNC:25048
OMIM 611348
CCDS CCDS31644
HPRD 12386
IMGT
EMBL AF172822 BC006369 BC008013 BC009859 BC009995 BC015664 BK005723
GenPept AAH06369 AAH08013 AAH09859 AAH09995 AAH15664 AAQ13616 DAA05723

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca