InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NR1H3

Summary

InnateDB Protein

IDBP-583631.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NR1H3

Protein Name

nuclear receptor subfamily 1, group H, member 3

Synonyms

LXR-a; LXRA; RLD-1;

Species

Homo sapiens

Ensembl Protein

ENSP00000434650

InnateDB Gene

IDBG-42877 (NR1H3)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 51 experimentally validated interaction(s) in this database.

Experimentally validated
Total	51 [view]
Protein-Protein	45 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0043401	steroid hormone mediated signaling pathway
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

InterPro

IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR008946 Nuclear hormone receptor, ligand-binding
IPR023257 Liver X receptor

PFAM

PF00104

PRINTS

PR02034

PIRSF

SMART

SM00430

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

E9PPA1

UniProt Splice Variant

Entrez Gene

10062

UniGene

Hs.438863

RefSeq

HUGO

HGNC:7966

OMIM

602423

CCDS

HPRD

07211

IMGT

EMBL

AC018410

GenPept