Version 5.4
Homo sapiens Protein: KRT8
Summary
InnateDB Protein IDBP-583673.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KRT8
Protein Name keratin 8
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000447566
InnateDB Gene IDBG-35198 (KRT8)
Protein Structure
UniProt Annotation
Function Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle. {ECO:0000269PubMed:16000376}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:10973561, ECO:0000269PubMed:19188445}. Nucleus, nucleoplasm {ECO:0000250}. Nucleus matrix {ECO:0000250}.
Disease Associations Cirrhosis (CIRRH) [MIM:215600]: A liver disease characterized by severe panlobular liver-cell swelling with Mallory body formation, prominent pericellular fibrosis, and marked deposits of copper. Clinical features include abdomen swelling, jaundice and pulmonary hypertension. {ECO:0000269PubMed:12724528}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Tissue Specificity Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma membrane in structures that contain dystrophin and spectrin. Expressed in gingival mucosa and hard palate of the oral cavity. {ECO:0000269PubMed:10973561, ECO:0000269PubMed:16000376}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 79 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 79 [view]
Protein-Protein 79 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
GO:0005515 protein binding
GO:0097110 scaffold protein binding
Biological Process
GO:0016032 viral process
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005882 intermediate filament
GO:0016363 nuclear matrix
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001664 Intermediate filament protein
IPR002957 Keratin, type I
IPR003054 Keratin, type II
IPR009053 Prefoldin
PFAM PF00038
PRINTS PR01248
PR01276
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P05787
PhosphoSite PhosphoSite-P05787
TrEMBL Q969I0
UniProt Splice Variant
Entrez Gene 3856
UniGene Hs.743772
RefSeq
HUGO HGNC:6446
OMIM 148060
CCDS CCDS8841
HPRD 01015
IMGT
EMBL AC107016 AK222941 AK290938 AK310257 AK315826 BC000654 BC008200 BC011373 BC063513 BC073760 BC075839 CH471054 M26512 M34225 M34482 U76549 X12882 X74929 X74981 X98614
GenPept AAA35748 AAA35763 AAA51542 AAB18966 AAH00654 AAH08200 AAH11373 AAH63513 AAH73760 AAH75839 BAD96661 BAF83627 BAF98717 CAA31376 CAA52882 CAA52916 CAA67203 EAW96653

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca