Homo sapiens Gene: KRT8
Summary
InnateDB Gene IDBG-35198.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KRT8
Gene Name keratin 8
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000170421
Encoded Proteins
keratin 8
keratin 8
keratin 8
keratin 8
keratin 8
keratin 8
keratin 8
keratin 8
keratin 8
keratin 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:52897187-52949954
Strand Reverse strand
Band q13.13
Transcripts
ENST00000293308 ENSP00000293308
ENST00000552551 ENSP00000447566
ENST00000546583
ENST00000550170
ENST00000546897 ENSP00000447402
ENST00000552150 ENSP00000449404
ENST00000547031
ENST00000549176
ENST00000546826 ENSP00000447881
ENST00000547176 ENSP00000449010
ENST00000548998 ENSP00000447040
ENST00000546900 ENSP00000450340
ENST00000547413 ENSP00000448681
ENST00000546542 ENSP00000450228
ENST00000549198
ENST00000552877
ENST00000551318
ENST00000546921
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 79 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 79 [view]
Protein-Protein 79 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
GO:0005515 protein binding
GO:0032403 protein complex binding
GO:0097110 scaffold protein binding
Biological Process
GO:0016032 viral process
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0045214 sarcomere organization
GO:0051599 response to hydrostatic pressure
GO:0051707 response to other organism
GO:0060706 cell differentiation involved in embryonic placenta development
GO:0097191 extrinsic apoptotic signaling pathway
GO:0097284 hepatocyte apoptotic process
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005882 intermediate filament
GO:0005911 cell-cell junction
GO:0016010 dystrophin-associated glycoprotein complex
GO:0016363 nuclear matrix
GO:0030018 Z disc
GO:0042383 sarcolemma
GO:0043034 costamere
GO:0045095 keratin filament
GO:0070062 extracellular vesicular exosome
GO:0071944 cell periphery
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
EGFR1 pathway
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Signaling mediated by p38-alpha and p38-beta
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.533782 Hs.743772
RefSeq NM_001256282 NM_001256293 NM_002273
HUGO
OMIM
CCDS CCDS58234 CCDS8841
HPRD 01015
IMGT
EMBL
GenPept
RNA Seq Atlas