InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: KRT8

Summary

InnateDB Gene

IDBG-35198.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KRT8

Gene Name

keratin 8

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000170421

Encoded Proteins

IDBP-35200

keratin 8

IDBP-583673

keratin 8

IDBP-602254

keratin 8

IDBP-594937

keratin 8

IDBP-594803

keratin 8

IDBP-601858

keratin 8

IDBP-600449

keratin 8

IDBP-598219

keratin 8

IDBP-584012

keratin 8

IDBP-602571

keratin 8

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:52897187-52949954

Strand

Reverse strand

Band

q13.13

Transcripts

ENST00000293308	ENSP00000293308
ENST00000552551	ENSP00000447566
ENST00000546583
ENST00000550170
ENST00000546897	ENSP00000447402
ENST00000552150	ENSP00000449404
ENST00000547031
ENST00000549176
ENST00000546826	ENSP00000447881
ENST00000547176	ENSP00000449010
ENST00000548998	ENSP00000447040
ENST00000546900	ENSP00000450340
ENST00000547413	ENSP00000448681
ENST00000546542	ENSP00000450228
ENST00000549198
ENST00000552877
ENST00000551318
ENST00000546921

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 79 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	79 [view]
Protein-Protein	79 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005198	structural molecule activity
GO:0005515	protein binding
GO:0032403	protein complex binding
GO:0097110	scaffold protein binding

Biological Process

GO:0016032	viral process
GO:0033209	tumor necrosis factor-mediated signaling pathway
GO:0045214	sarcomere organization
GO:0051599	response to hydrostatic pressure
GO:0051707	response to other organism
GO:0060706	cell differentiation involved in embryonic placenta development
GO:0097191	extrinsic apoptotic signaling pathway
GO:0097284	hepatocyte apoptotic process

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005882	intermediate filament
GO:0005911	cell-cell junction
GO:0016010	dystrophin-associated glycoprotein complex
GO:0016363	nuclear matrix
GO:0030018	Z disc
GO:0042383	sarcolemma
GO:0043034	costamere
GO:0045095	keratin filament
GO:0070062	extracellular vesicular exosome
GO:0071944	cell periphery

Orthologs

Species

Mus musculus

Gene ID

Gene Order

ENSMUSG00000049382

View Gene Order

Pathways

NETPATH

NetPath_4

EGFR1 pathway

REACTOME

KEGG

INOH

PID NCI

p38alphabetadownstreampathway

Signaling mediated by p38-alpha and p38-beta

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.533782 Hs.743772

RefSeq

NM_001256282 NM_001256293 NM_002273

HUGO

OMIM

CCDS

CCDS58234 CCDS8841

HPRD

01015

IMGT

EMBL

GenPept

RNA Seq Atlas