InnateDB Protein
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IDBP-583760.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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THRAP3
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Protein Name
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thyroid hormone receptor associated protein 3
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Synonyms
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TRAP150;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000433825
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InnateDB Gene
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IDBG-96334 (THRAP3)
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Protein Structure
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Function |
Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. {ECO:0000269PubMed:20123736, ECO:0000269PubMed:20932480, ECO:0000269PubMed:22424773, ECO:0000269PubMed:23525231}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:20123736, ECO:0000269PubMed:23525231}.
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Disease Associations |
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Tissue Specificity |
Ubiquitous. {ECO:0000269PubMed:10198638}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 108 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
108
[view]
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Protein-Protein |
104
[view]
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Protein-DNA |
4
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
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Biological Process |
GO:0000381
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regulation of alternative mRNA splicing, via spliceosome
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GO:0000956
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nuclear-transcribed mRNA catabolic process
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GO:0006367
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transcription initiation from RNA polymerase II promoter
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GO:0006397
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mRNA processing
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GO:0008380
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RNA splicing
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GO:0030518
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intracellular steroid hormone receptor signaling pathway
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GO:0030521
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androgen receptor signaling pathway
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GO:0045893
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positive regulation of transcription, DNA-templated
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GO:0045944
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positive regulation of transcription from RNA polymerase II promoter
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GO:0048026
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positive regulation of mRNA splicing, via spliceosome
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GO:0048255
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mRNA stabilization
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9Y2W1
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PhosphoSite |
PhosphoSite-Q9Y2W1
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TrEMBL |
E9PML1
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UniProt Splice Variant |
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Entrez Gene |
9967
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UniGene |
Hs.714892
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RefSeq |
XP_005271428
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HUGO |
HGNC:22964
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OMIM |
603809
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CCDS |
CCDS405
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HPRD |
07543
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IMGT |
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EMBL |
AC114484
AF117756
AL360074
AL591845
BC037554
BC112330
BC112350
CH471059
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GenPept |
AAD22034
AAH37554
AAI12331
AAI12351
CAH71859
EAX07379
EAX07380
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