InnateDB Protein
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IDBP-585130.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SIAE
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Protein Name
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sialic acid acetylesterase
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000437877
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InnateDB Gene
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IDBG-75227 (SIAE)
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Protein Structure
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Function |
Catalyzes the removal of O-acetyl ester groups from position 9 of the parent sialic acid, N-acetylneuraminic acid.
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Subcellular Localization |
Lysosome {ECO:0000305}. Secreted.
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Disease Associations |
Autoimmune disease 6 (AIS6) [MIM:613551]: Individuals manifesting susceptibility to autoimmune disease type 6 can suffer from juvenile idiopathic arthritis, rheumatoid arthritis, multiple sclerosis, Sjogren syndrome, systemic lupus erythematosus, type 1 diabetes, ulcerative colitis, and Crohn disease. {ECO:0000269PubMed:20555325}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
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Tissue Specificity |
Widely expressed with high expression in the testis, prostate, and colon. {ECO:0000269PubMed:15292578}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
Accession |
GO Term |
GO:0001681
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sialate O-acetylesterase activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR005181
Domain of unknown function DUF303, acetylesterase putative
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PFAM |
PF03629
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9HAT2
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PhosphoSite |
PhosphoSite-Q9HAT2
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
54414
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UniGene |
Hs.674805
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RefSeq |
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HUGO |
HGNC:18187
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OMIM |
610079
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CCDS |
CCDS55795
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HPRD |
16764
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IMGT |
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EMBL |
AF300796
AF303378
AK056093
AL137496
BC068450
CH471065
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GenPept |
AAG14897
AAG15386
AAH68450
BAG51622
CAB70771
EAW67591
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