Version 5.4
Homo sapiens Gene: SIAE
Summary
InnateDB Gene IDBG-75227.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SIAE
Gene Name sialic acid acetylesterase
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000110013
Encoded Proteins
IDBP-75229
sialic acid acetylesterase
IDBP-585130
sialic acid acetylesterase
IDBP-812726
sialic acid acetylesterase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an enzyme which removes 9-O-acetylation modifications from sialic acids. Mutations in this gene are associated with susceptibility to autoimmune disease 6. Multiple transcript variants encoding different isoforms, found either in the cytosol or in the lysosome, have been found for this gene.[provided by RefSeq, Feb 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:124633113-124695707
Strand Reverse strand
Band q24.2
Transcripts
ENST00000263593 ENSP00000263593
ENST00000436137
ENST00000533613
ENST00000525730
ENST00000545756 ENSP00000437877
ENST00000618733 ENSP00000478211
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001681 sialate O-acetylesterase activity
Biological Process
GO:0002682 regulation of immune system process
GO:0005975 carbohydrate metabolic process
Cellular Component
GO:0005615 extracellular space
GO:0005764 lysosome
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000001942
View Gene Order
ENSBTAG00000009412
Not yet available
Cross-References
SwissProt Q9HAT2
TrEMBL
UniProt Splice Variant
Entrez Gene 54414
UniGene Hs.576941 Hs.627388 Hs.674805
RefSeq NM_001199922 NM_170601
HUGO HGNC:18187
OMIM 610079
CCDS CCDS55795 CCDS8449
HPRD 16764
IMGT
EMBL AF300796 AF303378 AK056093 AL137496 BC068450 CH471065
GenPept AAG14897 AAG15386 AAH68450 BAG51622 CAB70771 EAW67591
RNA Seq Atlas 54414

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca