Homo sapiens Gene: SIAE
Summary
InnateDB Gene IDBG-75227.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SIAE
Gene Name sialic acid acetylesterase
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000110013
Encoded Proteins
sialic acid acetylesterase
sialic acid acetylesterase
sialic acid acetylesterase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an enzyme which removes 9-O-acetylation modifications from sialic acids. Mutations in this gene are associated with susceptibility to autoimmune disease 6. Multiple transcript variants encoding different isoforms, found either in the cytosol or in the lysosome, have been found for this gene.[provided by RefSeq, Feb 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:124633113-124695707
Strand Reverse strand
Band q24.2
Transcripts
ENST00000263593 ENSP00000263593
ENST00000436137
ENST00000533613
ENST00000525730
ENST00000545756 ENSP00000437877
ENST00000618733 ENSP00000478211
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001681 sialate O-acetylesterase activity
Biological Process
GO:0002682 regulation of immune system process
GO:0005975 carbohydrate metabolic process
Cellular Component
GO:0005615 extracellular space
GO:0005764 lysosome
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.576941 Hs.627388 Hs.674805
RefSeq NM_001199922 NM_170601
HUGO
OMIM
CCDS CCDS55795 CCDS8449
HPRD 16764
IMGT
EMBL
GenPept
RNA Seq Atlas