InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TIAM2

Summary

InnateDB Protein

IDBP-585357.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TIAM2

Protein Name

T-cell lymphoma invasion and metastasis 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000433348

InnateDB Gene

IDBG-98237 (TIAM2)

Protein Structure

UniProt Annotation

Function

Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP- dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by the accumulation of actin filaments along the altered plasma membrane (By similarity). Activates specifically RAC1, but not CDC42 and RHOA. {ECO:0000250, ECO:0000269PubMed:10512681}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Cell projection, filopodium {ECO:0000250}. Cell projection, growth cone. Note=Localizes to the plasma membrane in neurites. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in the occipital, frontal and temporal lobes, cerebellum, putamen and testis. {ECO:0000269PubMed:10512681}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005057	receptor signaling protein activity
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005515	protein binding

Biological Process

GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0032321	positive regulation of Rho GTPase activity
GO:0035023	regulation of Rho protein signal transduction
GO:0043065	positive regulation of apoptotic process
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0051056	regulation of small GTPase mediated signal transduction
GO:0097190	apoptotic signaling pathway

Cellular Component

GO:0005829	cytosol
GO:0030027	lamellipodium
GO:0030175	filopodium
GO:0030426	growth cone
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000219 Dbl homology (DH) domain
IPR001478 PDZ domain
IPR001849 Pleckstrin homology domain
IPR003116 Raf-like Ras-binding
IPR011072 HR1 rho-binding repeat

PFAM

PF00621
PF00595
PF13180
PF00169
PF02196
PF02185

PRINTS

PIRSF

SMART

SM00325
SM00228
SM00233
SM00455
SM00742

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8IVF5