Homo sapiens Gene: TIAM2
Summary
InnateDB Gene IDBG-98237.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TIAM2
Gene Name T-cell lymphoma invasion and metastasis 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000146426
Encoded Proteins
T-cell lymphoma invasion and metastasis 2
T-cell lymphoma invasion and metastasis 2
T-cell lymphoma invasion and metastasis 2
T-cell lymphoma invasion and metastasis 2
T-cell lymphoma invasion and metastasis 2
T-cell lymphoma invasion and metastasis 2
T-cell lymphoma invasion and metastasis 2
T-cell lymphoma invasion and metastasis 2
T-cell lymphoma invasion and metastasis 2
T-cell lymphoma invasion and metastasis 2
T-cell lymphoma invasion and metastasis 2
T-cell lymphoma invasion and metastasis 2
T-cell lymphoma invasion and metastasis 2
T-cell lymphoma invasion and metastasis 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a guanine nucleotide exchange factor. A highly similar mouse protein specifically activates ras-related C3 botulinum substrate 1, converting this Rho-like guanosine triphosphatase (GTPase) from a guanosine diphosphate-bound inactive state to a guanosine triphosphate-bound active state. The encoded protein may play a role in neural cell development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:154832697-155257723
Strand Forward strand
Band q25.2
Transcripts
ENST00000318981 ENSP00000327315
ENST00000360366 ENSP00000353528
ENST00000275246 ENSP00000275246
ENST00000431620
ENST00000449545
ENST00000456877 ENSP00000407183
ENST00000460692
ENST00000461783 ENSP00000437188
ENST00000462408 ENSP00000431269
ENST00000535064
ENST00000545347 ENSP00000444040
ENST00000538270 ENSP00000437435
ENST00000535231 ENSP00000443546
ENST00000528535 ENSP00000434901
ENST00000535583 ENSP00000442989
ENST00000529824 ENSP00000433348
ENST00000528391 ENSP00000435335
ENST00000543712 ENSP00000444897
ENST00000539296
ENST00000546145
ENST00000537845
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005057 receptor signaling protein activity
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0005096 GTPase activator activity
GO:0005515 protein binding
Biological Process
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0032321 positive regulation of Rho GTPase activity
GO:0035023 regulation of Rho protein signal transduction
GO:0035556 intracellular signal transduction
GO:0043065 positive regulation of apoptotic process
GO:0043087 regulation of GTPase activity
GO:0043547 positive regulation of GTPase activity
GO:0044255 cellular lipid metabolic process
GO:0044281 small molecule metabolic process
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0097190 apoptotic signaling pathway
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
GO:0030027 lamellipodium
GO:0030175 filopodium
GO:0030426 growth cone
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
G alpha (12/13) signalling events pathway
Signalling by NGF pathway
Metabolism of lipids and lipoproteins pathway
Signaling by Rho GTPases pathway
Signaling by GPCR pathway
p75 NTR receptor-mediated signalling pathway
PPARA activates gene expression pathway
Signal Transduction pathway
GPCR downstream signaling pathway
NRAGE signals death through JNK pathway
Rho GTPase cycle pathway
Cell death signalling via NRAGE, NRIF and NADE pathway
Fatty acid, triacylglycerol, and ketone body metabolism pathway
Metabolism pathway
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Regulation of RAC1 activity
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.486886 Hs.586279 Hs.733566 Hs.739388
RefSeq NM_001010927 NM_012454
HUGO
OMIM
CCDS CCDS34558 CCDS34559
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas