InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: VIM

Summary

InnateDB Protein

IDBP-58578.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

VIM

Protein Name

vimentin

Synonyms

CTRCT30; HEL113;

Species

Homo sapiens

Ensembl Protein

ENSP00000224237

InnateDB Gene

IDBG-58574 (VIM)

Protein Structure

UniProt Annotation

Function

Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. {ECO:0000269PubMed:21746880}.Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. {ECO:0000269PubMed:21746880}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:21465480}.

Disease Associations

Cataract 30 (CTRCT30) [MIM:116300]: An opacification of the crystalline lens of the eye that frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. In general, the more posteriorly located and dense an opacity, the greater the impact on visual function. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Highly expressed in fibroblasts, some expression in T- and B-lymphocytes, and little or no expression in Burkitt's lymphoma cell lines. Expressed in many hormone- independent mammary carcinoma cell lines. {ECO:0000269PubMed:2472876, ECO:0000269PubMed:3371665}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 278 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	278 [view]
Protein-Protein	276 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001948	glycoprotein binding
GO:0003725	double-stranded RNA binding
GO:0005198	structural molecule activity
GO:0005200	structural constituent of cytoskeleton
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0042802	identical protein binding
GO:0097110	scaffold protein binding

Biological Process

GO:0006915	apoptotic process
GO:0006921	cellular component disassembly involved in execution phase of apoptosis
GO:0006928	cellular component movement
GO:0016032	viral process
GO:0030049	muscle filament sliding

Cellular Component

GO:0005737	cytoplasm
GO:0005777	peroxisome
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005882	intermediate filament
GO:0005886	plasma membrane
GO:0045111	intermediate filament cytoskeleton
GO:0070062	extracellular vesicular exosome