InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: JMJD1C

Summary

InnateDB Protein

IDBP-585808.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

JMJD1C

Protein Name

jumonji domain containing 1C

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000444682

InnateDB Gene

IDBG-75649 (JMJD1C)

Protein Structure

UniProt Annotation

Function

Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	21 [view]
Protein-Protein	21 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0046872	metal ion binding
GO:0046966	thyroid hormone receptor binding
GO:0051213	dioxygenase activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007596	blood coagulation
GO:0016568	chromatin modification
GO:0055114	oxidation-reduction process