InnateDB Protein
|
IDBP-585860.3
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
TTLL5
|
Protein Name
|
tubulin tyrosine ligase-like family, member 5
|
Synonyms
|
CORD19; KIAA0998; STAMP;
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000452524
|
InnateDB Gene
|
IDBG-13099 (TTLL5)
|
Protein Structure
|
|
Function |
Polyglutamylase which preferentially modifies alpha- tubulin. Involved in the side-chain initiation step of the polyglutamylation reaction rather than in the elongation step (By similarity). Required for CCSAP localization to both spindle and cilia microtubules. Increases the effects of NCOA2 in glucocorticoid receptor-mediated repression and induction and in androgen receptor-mediated induction. {ECO:0000250, ECO:0000269PubMed:17116691, ECO:0000269PubMed:22493317}.
|
Subcellular Localization |
Cell projection, cilium {ECO:0000250}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250}. Nucleus {ECO:0000269PubMed:17116691}. Cytoplasm {ECO:0000269PubMed:17116691}. Note=In ciliated cells, located in both cilia and basal bodies (By similarity). In osteosarcoma cells, found in both cytoplasm and nucleus in the absence of steroid but located exclusively in the nucleus in the presence of steroid. {ECO:0000250}.
|
Disease Associations |
|
Tissue Specificity |
Widely expressed with highest levels in heart and skeletal muscle and low levels in other tissues. {ECO:0000269PubMed:17116691}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
5
[view]
|
Protein-Protein |
5
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
|
PFAM |
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q6EMB2
|
PhosphoSite |
PhosphoSite-Q6EMB2
|
TrEMBL |
O95419
|
UniProt Splice Variant |
|
Entrez Gene |
23093
|
UniGene |
Hs.709609
|
RefSeq |
|
HUGO |
HGNC:19963
|
OMIM |
612268
|
CCDS |
|
HPRD |
08309
|
IMGT |
|
EMBL |
AB023215
AC007182
AC009399
AF107885
AK024259
AL136808
AY237126
BC002766
BC136472
BC136473
CH471061
CR533554
|
GenPept |
AAC79729
AAF23275
AAH02766
AAI36473
AAI36474
AAP75557
BAA76842
BAB14862
CAB66742
CAG38585
EAW81247
|
|
|