Version 5.4
Homo sapiens Protein: GRP
Summary
InnateDB Protein IDBP-586114.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GRP
Protein Name gastrin-releasing peptide
Synonyms BN; GRP-10; preproGRP; proGRP;
Species Homo sapiens
Ensembl Protein ENSP00000434101
InnateDB Gene IDBG-4030 (GRP)
Protein Structure
UniProt Annotation
Function GRP stimulates gastrin release as well as other gastrointestinal hormones. Operates as a negative feedback regulating fear and established a causal relationship between GRP- receptor gene expression, long-term potentiation, and amygdala- dependent memory for fear (By similarity). {ECO:0000250}.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 0
Protein-DNA 0
Protein-RNA 3 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005184 neuropeptide hormone activity
Biological Process
GO:0007165 signal transduction
GO:0007218 neuropeptide signaling pathway
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Protein Structure and Domains
PDB ID
InterPro IPR000874 Bombesin/neuromedin-B/ranatensin peptide family
PFAM PF02044
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P07492
PhosphoSite PhosphoSite-P07492
TrEMBL
UniProt Splice Variant
Entrez Gene 2922
UniGene Hs.153444
RefSeq NP_001012531
HUGO HGNC:4605
OMIM 137260
CCDS CCDS45878
HPRD 08845
IMGT
EMBL AC067859 BC004488 BT006803 CH471096 K02054 M12511 M12512 M12550
GenPept AAA52611 AAA52612 AAA52613 AAH04488 AAP35449 EAW63091

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca