Version 5.4
| Homo sapiens Gene: GRP | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-4030.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | GRP | ||||||||||||||||||
| Gene Name | gastrin-releasing peptide | ||||||||||||||||||
| Synonyms | BN; GRP-10; preproGRP; proGRP | ||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000134443 | ||||||||||||||||||
| Encoded Proteins |
gastrin-releasing peptide
gastrin-releasing peptide
gastrin-releasing peptide
gastrin-releasing peptide
gastrin-releasing peptide
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| Protein Structure | |||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
This gene encodes a member of the bombesin-like family of gastrin-releasing peptides. Its preproprotein, following cleavage of a signal peptide, is further processed to produce either the 27 aa gastrin-releasing peptide or the 10 aa neuromedin C. These smaller peptides regulate numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation. These peptides are also likely to play a role in human cancers of the lung, colon, stomach, pancreas, breast, and prostate. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 18:59220168-59230774 | ||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||
| Band | q21.32 | ||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
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Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME |
G alpha (q) signalling events pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
Peptide ligand-binding receptors pathway
Class A/1 (Rhodopsin-like receptors) pathway
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) pathway
Signaling by GPCR pathway
Signal Transduction pathway
GPCR downstream signaling pathway
Incretin synthesis, secretion, and inactivation pathway
Metabolism of proteins pathway
GPCR ligand binding pathway
Peptide hormone metabolism pathway
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| KEGG | |||||||||||||||||||
| INOH |
GPCR signaling pathway
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| PID NCI | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | |||||||||||||||||||
| TrEMBL | |||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| UniGene | Hs.153444 | ||||||||||||||||||
| RefSeq | NM_001012512 NM_001012513 NM_002091 XM_006722442 | ||||||||||||||||||
| HUGO | |||||||||||||||||||
| OMIM | |||||||||||||||||||
| CCDS | CCDS11971 CCDS45877 CCDS45878 | ||||||||||||||||||
| HPRD | 08845 | ||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | |||||||||||||||||||
| GenPept | |||||||||||||||||||
| RNA Seq Atlas | |||||||||||||||||||