InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GMPR2

Summary

InnateDB Protein

IDBP-586128.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GMPR2

Protein Name

guanosine monophosphate reductase 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000453299

InnateDB Gene

IDBG-3727 (GMPR2)

Protein Structure

UniProt Annotation

Function

Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. Plays a role in modulating cellular differentiation. {ECO:0000269PubMed:12009299, ECO:0000269PubMed:12669231, ECO:0000269PubMed:16359702, ECO:0000269PubMed:22037469}.

Subcellular Localization

Disease Associations

Tissue Specificity

Highly expressed in heart, skeletal muscle, kidney, brain, liver, prostate, spleen, placenta, testis and ovary. Low expression in colon, thymus and peripheral blood leukocytes. {ECO:0000269PubMed:12009299, ECO:0000269PubMed:12669231}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	5 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0003920	GMP reductase activity
GO:0016491	oxidoreductase activity
GO:0046872	metal ion binding

Biological Process

GO:0006144	purine nucleobase metabolic process
GO:0008152	metabolic process
GO:0009117	nucleotide metabolic process
GO:0043101	purine-containing compound salvage
GO:0044281	small molecule metabolic process
GO:0046037	GMP metabolic process
GO:0055086	nucleobase-containing small molecule metabolic process
GO:0055114	oxidation-reduction process