InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KLF11

Summary

InnateDB Protein

IDBP-586425.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KLF11

Protein Name

Kruppel-like factor 11

Synonyms

FKLF; FKLF1; MODY7; TIEG2; Tieg3;

Species

Homo sapiens

Ensembl Protein

ENSP00000442722

InnateDB Gene

IDBG-28160 (KLF11)

Protein Structure

UniProt Annotation

Function

Transcription factor. Activates the epsilon- and gamma- globin gene promoters and, to a much lower degree, the beta-globin gene and represses promoters containing SP1-like binding inhibiting cell growth. Represses transcription of SMAD7 which enhances TGF-beta signaling. Induces apoptosis. {ECO:0000269PubMed:10207080}.

Subcellular Localization

Nucleus.

Disease Associations

Maturity-onset diabetes of the young 7 (MODY7) [MIM:610508]: A form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease. {ECO:0000269PubMed:15774581}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Ubiquitous. Higher expression in erythroid cells. {ECO:0000269PubMed:10207080}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	22 [view]
Protein-Protein	20 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0044212	transcription regulatory region DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0006915	apoptotic process
GO:0008285	negative regulation of cell proliferation
GO:0043065	positive regulation of apoptotic process