InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PRPF4B

Summary

InnateDB Protein

IDBP-586610.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PRPF4B

Protein Name

PRP4 pre-mRNA processing factor 4 homolog B (yeast)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000433547

InnateDB Gene

IDBG-57906 (PRPF4B)

Protein Structure

UniProt Annotation

Function

Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Ubiquitous.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 49 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	49 [view]
Protein-Protein	49 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000398	mRNA splicing, via spliceosome
GO:0006468	protein phosphorylation
GO:0008380	RNA splicing

Cellular Component

GO:0005634	nucleus
GO:0071013	catalytic step 2 spliceosome

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt