Version 5.4
Homo sapiens Gene: PRPF4B
Summary
InnateDB Gene IDBG-57906.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PRPF4B
Gene Name PRP4 pre-mRNA processing factor 4 homolog B (yeast)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000112739
Encoded Proteins
IDBP-57908
PRP4 pre-mRNA processing factor 4 homolog B (yeast)
IDBP-586610
PRP4 pre-mRNA processing factor 4 homolog B (yeast)
IDBP-597225
PRP4 pre-mRNA processing factor 4 homolog B (yeast)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Pre-mRNA splicing occurs in two sequential transesterification steps, and the protein encoded by this gene is thought to be involved in pre-mRNA splicing and in signal transduction. This protein belongs to a kinase family that includes serine/arginine-rich protein-specific kinases and cyclin-dependent kinases (CDKs). This protein is regarded as a CDK-like kinase (Clk) with homology to mitogen-activated protein kinases (MAPKs). [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:4021267-4064983
Strand Forward strand
Band p25.2
Transcripts
ENST00000337659 ENSP00000337194
ENST00000480058 ENSP00000433547
ENST00000481109 ENSP00000433714
ENST00000490399
ENST00000463634
ENST00000466185
ENST00000494674
ENST00000490653
ENST00000461612
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 49 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 49 [view]
Protein-Protein 49 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0006468 protein phosphorylation
GO:0008380 RNA splicing
Cellular Component
GO:0005634 nucleus
GO:0005694 chromosome
GO:0071013 catalytic step 2 spliceosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021413
View Gene Order
ENSBTAG00000002086
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
NetPath_11
TCR pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL H0YDJ3
UniProt Splice Variant
Entrez Gene 8899
UniGene Hs.686494 Hs.690680
RefSeq NM_003913
HUGO HGNC:17346
OMIM 602338
CCDS CCDS4488
HPRD 09087
IMGT
EMBL AL033383 AL138831
GenPept
RNA Seq Atlas 8899

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca