Version 5.4
Homo sapiens Protein: CTNNA2
Summary
InnateDB Protein IDBP-586697.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CTNNA2
Protein Name catenin (cadherin-associated protein), alpha 2
Synonyms CAP-R; CAPR; CT114; CTNR;
Species Homo sapiens
Ensembl Protein ENSP00000441705
InnateDB Gene IDBG-58519 (CTNNA2)
Protein Structure
UniProt Annotation
Function May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system. Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of startle modulation (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:16182284}. Cytoplasm, cytoskeleton {ECO:0000250}. Cell junction, adherens junction {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cell projection, axon {ECO:0000250}. Note=Recruited to the nucleus upon ZNF639 overexpression.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005200 structural constituent of cytoskeleton
GO:0005515 protein binding
GO:0045296 cadherin binding
GO:0051015 actin filament binding
Biological Process
GO:0007155 cell adhesion
GO:0007409 axonogenesis
GO:0016337 single organismal cell-cell adhesion
GO:0021942 radial glia guided migration of Purkinje cell
GO:0042692 muscle cell differentiation
GO:0048813 dendrite morphogenesis
GO:0048854 brain morphogenesis
GO:0051149 positive regulation of muscle cell differentiation
GO:0051823 regulation of synapse structural plasticity
GO:0060134 prepulse inhibition
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005912 adherens junction
GO:0015629 actin cytoskeleton
GO:0030424 axon
Protein Structure and Domains
PDB ID
InterPro IPR001033 Alpha-catenin
IPR006077 Vinculin/alpha-catenin
PFAM PF01044
PRINTS PR00805
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P26232
PhosphoSite PhosphoSite-P26232
TrEMBL
UniProt Splice Variant
Entrez Gene 1496
UniGene Hs.167368
RefSeq
HUGO HGNC:2510
OMIM 114025
CCDS
HPRD 00228
IMGT
EMBL AC008067 AC010975 AC011741 AC011746 AC016670 AC016716 AC093322 AC096573 AC096753 AC104780 AK127226 AK295181 AK295493 AK303035 BC052996 BX537769 CH471053 FJ695201 M94151
GenPept AAA58407 AAH52996 AAX88946 AAX93241 AAY14758 AAY14763 AAY15008 AAY15073 BAG54457 BAH12003 BAH12088 BAH13884 CAD97832 EAW99564 EAW99565

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca