Version 5.4
Homo sapiens Protein: EPN3
Summary
InnateDB Protein IDBP-58728.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EPN3
Protein Name epsin 3
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000268933
InnateDB Gene IDBG-58726 (EPN3)
Protein Structure
UniProt Annotation
Function
Subcellular Localization Cytoplasm {ECO:0000269PubMed:11359770}. Cytoplasm, perinuclear region {ECO:0000269PubMed:11359770}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000269PubMed:11359770}. Nucleus {ECO:0000305PubMed:11359770}. Note=Concentrated in the perinuclear region and associated with clathrin-coated vesicles close to the cell periphery. May shuttle to the nucleus.
Disease Associations
Tissue Specificity Detected in migrating keratinocytes from wounded skin, but not in differentiating keratinocytes or in normal skin. Detected in chronic wounds, basal cell carcinoma and ulcerative colitis. {ECO:0000269PubMed:11359770}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005543 phospholipid binding
GO:0008289 lipid binding
GO:1990175 EH domain binding
Biological Process
Cellular Component
GO:0005634 nucleus
GO:0005905 coated pit
GO:0019897 extrinsic component of plasma membrane
GO:0030136 clathrin-coated vesicle
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001026 Epsin domain, N-terminal
IPR003903 Ubiquitin interacting motif
IPR008942 ENTH/VHS
IPR011417 AP180 N-terminal homology (ANTH) domain
IPR013809 Epsin-like, N-terminal
PFAM PF01417
PF02809
PF07651
PRINTS
PIRSF
SMART SM00726
SM00273
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9H201
PhosphoSite PhosphoSite-Q9H201
TrEMBL D6RFG3
UniProt Splice Variant
Entrez Gene 55040
UniGene Hs.740136
RefSeq NP_060427
HUGO HGNC:18235
OMIM 607264
CCDS CCDS11570
HPRD 06272
IMGT
EMBL AC021491 AF324241 AK000785 AK291658 AK292977 BC001038 BC051365 BC077722 CH471109
GenPept AAG45223 BAA91378 BAF84347 BAF85666 EAW94607

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca