InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ATF3

Summary

InnateDB Protein

IDBP-587976.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATF3

Protein Name

activating transcription factor 3

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000432208

InnateDB Gene

IDBG-106549 (ATF3)

Protein Structure

UniProt Annotation

Function

This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Represses transcription from promoters with ATF sites. It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter. Isoform 2 activates transcription presumably by sequestering inhibitory cofactors away from the promoters.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00978, ECO:0000269PubMed:12034827}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 82 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	82 [view]
Protein-Protein	71 [view]
Protein-DNA	8 [view]
Protein-RNA	3 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001228	RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0042802	identical protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006987	activation of signaling protein activity involved in unfolded protein response
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0044267	cellular protein metabolic process
GO:0045087	innate immune response (InnateDB)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter