Homo sapiens Gene: ATF3
Summary
InnateDB Gene IDBG-106549.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ATF3
Gene Name activating transcription factor 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000162772
Encoded Proteins
activating transcription factor 3
activating transcription factor 3
activating transcription factor 3
activating transcription factor 3
activating transcription factor 3
activating transcription factor 3
activating transcription factor 3
activating transcription factor 3
activating transcription factor 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
ATF3 is induced by lipopolysaccharide (LPS) and regulates TLR-stimulated inflammatory responses as part of a negative-feedback loop.
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Atf3 has been identified as a high-density lipoprotein ??inducible negative regulator of macrophage activation.
[Mus musculus] Atf3 plays an important role in modulating IFN responses in macrophages by controlling basal and inducible levels of Ifnb1, as well as the expression of genes downstream of IFN signalling.
Entrez Gene
Summary This gene encodes a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. This gene is induced by a variety of signals, including many of those encountered by cancer cells, and is involved in the complex process of cellular stress response. Multiple transcript variants encoding different isoforms have been found for this gene. It is possible that alternative splicing of this gene may be physiologically important in the regulation of target genes. [provided by RefSeq, Apr 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:212565334-212620777
Strand Forward strand
Band q32.3
Transcripts
ENST00000366987 ENSP00000355954
ENST00000341491 ENSP00000344352
ENST00000366985 ENSP00000355952
ENST00000366983 ENSP00000355950
ENST00000336937 ENSP00000336908
ENST00000366981 ENSP00000355948
ENST00000465155
ENST00000492118
ENST00000464547 ENSP00000432208
ENST00000613104 ENSP00000480606
ENST00000613954 ENSP00000483576
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 82 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 82 [view]
Protein-Protein 71 [view]
Protein-DNA 8 [view]
Protein-RNA 3 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0001228 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0042802 identical protein binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006094 gluconeogenesis
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006987 activation of signaling protein activity involved in unfolded protein response
GO:0008284 positive regulation of cell proliferation
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0035914 skeletal muscle cell differentiation
GO:0044267 cellular protein metabolic process
GO:0045087 innate immune response (InnateDB)
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
ID pathway
TGF_beta_Receptor pathway
REACTOME
Unfolded Protein Response (UPR) pathway
ATF4 activates genes pathway
Metabolism of proteins pathway
PERK regulates gene expression pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Direct p53 effectors
ATF-2 transcription factor network
AP-1 transcription factor network
Regulation of nuclear SMAD2/3 signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001030287 NM_001040619 NM_001206484 NM_001206486 NM_001206488 NM_001674
HUGO
OMIM
CCDS CCDS1506 CCDS41464 CCDS55688 CCDS58059
HPRD 04395
IMGT
EMBL
GenPept
RNA Seq Atlas