Version 5.4
Homo sapiens Gene: ATF3
Summary
InnateDB Gene IDBG-106549.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ATF3
Gene Name activating transcription factor 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000162772
Encoded Proteins
IDBP-106551
activating transcription factor 3
IDBP-106553
activating transcription factor 3
IDBP-106555
activating transcription factor 3
IDBP-106557
activating transcription factor 3
IDBP-106559
activating transcription factor 3
IDBP-106563
activating transcription factor 3
IDBP-587976
activating transcription factor 3
IDBP-812265
activating transcription factor 3
IDBP-812269
activating transcription factor 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 16688168
ATF3 is induced by lipopolysaccharide (LPS) and regulates TLR-stimulated inflammatory responses as part of a negative-feedback loop.
InnateDB Annotation from Orthologs
Summary
PMID 24317040
[Mus musculus] Atf3 has been identified as a high-density lipoprotein â??inducible negative regulator of macrophage activation.
PMID 26416280
[Mus musculus] Atf3 plays an important role in modulating IFN responses in macrophages by controlling basal and inducible levels of Ifnb1, as well as the expression of genes downstream of IFN signalling.
Entrez Gene
Summary This gene encodes a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. This gene is induced by a variety of signals, including many of those encountered by cancer cells, and is involved in the complex process of cellular stress response. Multiple transcript variants encoding different isoforms have been found for this gene. It is possible that alternative splicing of this gene may be physiologically important in the regulation of target genes. [provided by RefSeq, Apr 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:212565334-212620777
Strand Forward strand
Band q32.3
Transcripts
ENST00000366987 ENSP00000355954
ENST00000341491 ENSP00000344352
ENST00000366985 ENSP00000355952
ENST00000366983 ENSP00000355950
ENST00000336937 ENSP00000336908
ENST00000366981 ENSP00000355948
ENST00000465155
ENST00000492118
ENST00000464547 ENSP00000432208
ENST00000613104 ENSP00000480606
ENST00000613954 ENSP00000483576
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 82 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 82 [view]
Protein-Protein 71 [view]
Protein-DNA 8 [view]
Protein-RNA 3 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0001228 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0042802 identical protein binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006094 gluconeogenesis
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006987 activation of signaling protein activity involved in unfolded protein response
GO:0008284 positive regulation of cell proliferation
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0035914 skeletal muscle cell differentiation
GO:0044267 cellular protein metabolic process
GO:0045087 innate immune response (InnateDB)
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026628
View Gene Order
ENSBTAG00000008545
Not yet available
Pathways
NETPATH
NetPath_5
ID pathway
NetPath_7
TGF_beta_Receptor pathway
REACTOME
REACT_18355
ATF4 activates genes pathway
REACT_18277
PERK regulates gene expression pathway
REACT_18356
Unfolded Protein Response (UPR) pathway
REACT_17015
Metabolism of proteins pathway
KEGG
INOH
PID NCI
p53downstreampathway
Direct p53 effectors
atf2_pathway
ATF-2 transcription factor network
ap1_pathway
AP-1 transcription factor network
smad2_3nuclearpathway
Regulation of nuclear SMAD2/3 signaling
Cross-References
SwissProt P18847
TrEMBL Q8NG55
UniProt Splice Variant
Entrez Gene 467
UniGene
RefSeq NM_001030287 NM_001040619 NM_001206484 NM_001206486 NM_001206488 NM_001674
HUGO HGNC:785
OMIM 603148
CCDS CCDS41464 CCDS1506 CCDS55688 CCDS58059
HPRD 04395
IMGT
EMBL AB066566 AB078026 AB078027 AB078028 AC092803 AK312998 AL590648 AL606913 AY313927 AY426987 BC006322 BT006996 CH471100 CR450334 DA589280 L19871
GenPept AAA20506 AAH06322 AAP35642 AAP93896 AAQ93358 BAB84092 BAC00495 BAC00496 BAC05510 BAG35834 CAG29330 CAH72653 CAH72654 CAH72656 EAW93385 EAW93386 EAW93387 EAW93388
RNA Seq Atlas 467

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca