InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC11A1

Summary

InnateDB Protein

IDBP-588587.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC11A1

Protein Name

solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1

Synonyms

LSH; NRAMP; NRAMP1;

Species

Homo sapiens

Ensembl Protein

ENSP00000443435

InnateDB Gene

IDBG-80969 (SLC11A1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	0
Protein-DNA	6 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005384	manganese ion transmembrane transporter activity
GO:0042803	protein homodimerization activity
GO:0046915	transition metal ion transmembrane transporter activity
GO:0051139	metal ion:proton antiporter activity

Biological Process

GO:0001818	negative regulation of cytokine production
GO:0001819	positive regulation of cytokine production
GO:0002309	T cell proliferation involved in immune response
GO:0002369	T cell cytokine production
GO:0002606	positive regulation of dendritic cell antigen processing and presentation
GO:0002827	positive regulation of T-helper 1 type immune response
GO:0006826	iron ion transport
GO:0006828	manganese ion transport
GO:0006876	cellular cadmium ion homeostasis
GO:0006879	cellular iron ion homeostasis
GO:0006909	phagocytosis
GO:0006954	inflammatory response
GO:0007035	vacuolar acidification
GO:0009617	response to bacterium
GO:0010628	positive regulation of gene expression
GO:0015707	nitrite transport
GO:0032147	activation of protein kinase activity
GO:0032496	response to lipopolysaccharide
GO:0032623	interleukin-2 production
GO:0032632	interleukin-3 production
GO:0032729	positive regulation of interferon-gamma production
GO:0034341	response to interferon-gamma
GO:0042060	wound healing
GO:0042116	macrophage activation
GO:0042742	defense response to bacterium
GO:0042832	defense response to protozoan
GO:0043091	L-arginine import
GO:0045342	MHC class II biosynthetic process
GO:0045730	respiratory burst
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048002	antigen processing and presentation of peptide antigen
GO:0048255	mRNA stabilization
GO:0050766	positive regulation of phagocytosis
GO:0050829	defense response to Gram-negative bacterium
GO:0051701	interaction with host
GO:0055072	iron ion homeostasis
GO:0055085	transmembrane transport
GO:0060586	multicellular organismal iron ion homeostasis
GO:0070574	cadmium ion transmembrane transport
GO:0070839	divalent metal ion export
GO:0090382	phagosome maturation

Cellular Component

GO:0005764	lysosome
GO:0005770	late endosome
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0030670	phagocytic vesicle membrane
GO:0031902	late endosome membrane
GO:0070821	tertiary granule membrane