Version 5.4
Homo sapiens Gene: SLC11A1
Summary
InnateDB Gene IDBG-80969.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC11A1
Gene Name solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1
Synonyms LSH; NRAMP; NRAMP1
Species Homo sapiens
Ensembl Gene ENSG00000018280
Encoded Proteins
IDBP-80971
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1
IDBP-80973
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1
IDBP-810933
solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
IDBP-810943
solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
IDBP-588587
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 25350459
[Mus musculus] Slc11a1 confers temporal and anatomical host resistance to chronic Salmonella infection.
Entrez Gene
Summary This gene is a member of the solute carrier family 11 (proton-coupled divalent metal ion transporters) family and encodes a multi-pass membrane protein. The protein functions as a divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Mutations in this gene have been associated with susceptibility to infectious diseases such as tuberculosis and leprosy, and inflammatory diseases such as rheumatoid arthritis and Crohn disease. Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:218382029-218396894
Strand Forward strand
Band q35
Transcripts
ENST00000233202 ENSP00000233202
ENST00000354352 ENSP00000346320
ENST00000468221
ENST00000473367 ENSP00000484905
ENST00000465984
ENST00000481524 ENSP00000483970
ENST00000494322
ENST00000471875
ENST00000469799
ENST00000492413
ENST00000475225
ENST00000469449
ENST00000483487
ENST00000460592
ENST00000490872
ENST00000490536
ENST00000468721
ENST00000539932 ENSP00000443435
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 0
Protein-DNA 6 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005215 transporter activity
GO:0005384 manganese ion transmembrane transporter activity
GO:0042803 protein homodimerization activity
GO:0046915 transition metal ion transmembrane transporter activity
GO:0051139 metal ion:proton antiporter activity
Biological Process
GO:0000060 protein import into nucleus, translocation
GO:0001818 negative regulation of cytokine production
GO:0001819 positive regulation of cytokine production
GO:0002309 T cell proliferation involved in immune response
GO:0002369 T cell cytokine production
GO:0002606 positive regulation of dendritic cell antigen processing and presentation
GO:0002827 positive regulation of T-helper 1 type immune response
GO:0006810 transport
GO:0006826 iron ion transport
GO:0006828 manganese ion transport
GO:0006876 cellular cadmium ion homeostasis
GO:0006879 cellular iron ion homeostasis
GO:0006909 phagocytosis
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007035 vacuolar acidification
GO:0009617 response to bacterium
GO:0010628 positive regulation of gene expression
GO:0015707 nitrite transport
GO:0032147 activation of protein kinase activity
GO:0032496 response to lipopolysaccharide
GO:0032623 interleukin-2 production
GO:0032632 interleukin-3 production
GO:0032729 positive regulation of interferon-gamma production
GO:0034341 response to interferon-gamma
GO:0042060 wound healing
GO:0042116 macrophage activation
GO:0042742 defense response to bacterium
GO:0042832 defense response to protozoan
GO:0043091 L-arginine import
GO:0045342 MHC class II biosynthetic process
GO:0045730 respiratory burst
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048002 antigen processing and presentation of peptide antigen
GO:0048255 mRNA stabilization
GO:0050766 positive regulation of phagocytosis
GO:0050829 defense response to Gram-negative bacterium
GO:0051701 interaction with host
GO:0055072 iron ion homeostasis
GO:0055085 transmembrane transport
GO:0060586 multicellular organismal iron ion homeostasis
GO:0070574 cadmium ion transmembrane transport
GO:0070839 divalent metal ion export
GO:0071421 manganese ion transmembrane transport
GO:0090382 phagosome maturation
Cellular Component
GO:0005575 cellular_component
GO:0005764 lysosome
GO:0005770 late endosome
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009279 cell outer membrane
GO:0010008 endosome membrane
GO:0016020 membrane
GO:0030670 phagocytic vesicle membrane
GO:0031902 late endosome membrane
GO:0070821 tertiary granule membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026177
View Gene Order
ENSBTAG00000015520
Not yet available
Pathways
NETPATH
REACTOME
REACT_20547
Metal ion SLC transporters pathway
REACT_19305
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds pathway
REACT_121256
Phagosomal maturation (early endosomal stage) pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_19118
SLC-mediated transmembrane transport pathway
REACT_121237
Latent infection of Homo sapiens with Mycobacterium tuberculosis pathway
REACT_116125
Disease pathway
KEGG
hsa04142
Lysosome pathway
INOH
PID NCI
myc_represspathway
Validated targets of C-MYC transcriptional repression
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.591607 Hs.627035
RefSeq NM_000578 XM_005246793 XM_006712710 XM_006712711
HUGO
OMIM
CCDS CCDS2415
HPRD 02601
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca