InnateDB Protein
|
IDBP-588937.3
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
NUDT4
|
Protein Name
|
nudix (nucleoside diphosphate linked moiety X)-type motif 4
|
Synonyms
|
DIPP2; DIPP2alpha; DIPP2beta;
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000448032
|
InnateDB Gene
|
IDBG-51175 (NUDT4)
|
Protein Structure
|
|
Function |
Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), PP-InsP4 and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphate Ap6A, but not Ap5A. The major reaction products are ADP and p4a from Ap6A. Also able to hydrolyze 5-phosphoribose 1-diphosphate. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA. {ECO:0000269PubMed:10777568}.
|
Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:12121577}.
|
Disease Associations |
|
Tissue Specificity |
Expressed in heart and, at lower level in skeletal muscle, pancreas and kidney. {ECO:0000269PubMed:10777568}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
|
Protein-Protein |
1
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
|
|
Molecular Function |
Accession |
GO Term |
GO:0008486
|
diphosphoinositol-polyphosphate diphosphatase activity
|
GO:0016787
|
hydrolase activity
|
GO:0030515
|
snoRNA binding
|
GO:0046872
|
metal ion binding
|
GO:0052840
|
inositol diphosphate tetrakisphosphate diphosphatase activity
|
GO:0052843
|
inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity
|
GO:0052844
|
inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity
|
GO:0052845
|
inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity
|
GO:0052846
|
inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity
|
GO:0052847
|
inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity
|
GO:0052848
|
inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity
|
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR000086
NUDIX hydrolase domain
IPR015797
NUDIX hydrolase domain-like
|
PFAM |
PF00293
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q9NZJ9
|
PhosphoSite |
PhosphoSite-Q9NZJ9
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
11163
|
UniGene |
Hs.735514
|
RefSeq |
NP_001287951
|
HUGO |
HGNC:8051
|
OMIM |
609229
|
CCDS |
CCDS73504
|
HPRD |
14850
|
IMGT |
|
EMBL |
AB007956
AF067803
AF191649
AF191650
AF191651
AF191652
AF191653
AK223497
AK304296
BC012069
BC051310
BT020109
BT020110
CR749445
|
GenPept |
AAF68855
AAF68856
AAF68857
AAF68858
AAF68859
AAF75563
AAH12069
AAH51310
AAV38912
AAV38913
BAD97217
BAE16985
BAH14152
CAH18283
|
|
|