Version 5.4
Homo sapiens Gene: NUDT4
Summary
InnateDB Gene IDBG-51175.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NUDT4
Gene Name nudix (nucleoside diphosphate linked moiety X)-type motif 4
Synonyms DIPP2; DIPP2alpha; DIPP2beta
Species Homo sapiens
Ensembl Gene ENSG00000173598
Encoded Proteins
IDBP-51177
nudix (nucleoside diphosphate linked moiety X)-type motif 4
IDBP-381122
nudix (nucleoside diphosphate linked moiety X)-type motif 4
IDBP-597995
nudix (nucleoside diphosphate linked moiety X)-type motif 4
IDBP-592420
nudix (nucleoside diphosphate linked moiety X)-type motif 4
IDBP-603638
nudix (nucleoside diphosphate linked moiety X)-type motif 4
IDBP-588937
nudix (nucleoside diphosphate linked moiety X)-type motif 4
IDBP-589397
nudix (nucleoside diphosphate linked moiety X)-type motif 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene regulates the turnover of diphosphoinositol polyphosphates. The turnover of these high-energy diphosphoinositol polyphosphates represents a molecular switching activity with important regulatory consequences. Molecular switching by diphosphoinositol polyphosphates may contribute to regulating intracellular trafficking. Several alternatively spliced transcript variants have been described, but the full-length nature of some variants has not been determined. Isoforms DIPP2alpha and DIPP2beta are distinguishable from each other solely by DIPP2beta possessing one additional amino acid due to intron boundary skidding in alternate splicing. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:93377883-93408146
Strand Forward strand
Band q22
Transcripts
ENST00000337179 ENSP00000338352
ENST00000415493 ENSP00000406612
ENST00000550056 ENSP00000448504
ENST00000549992 ENSP00000449552
ENST00000548662 ENSP00000449724
ENST00000547014 ENSP00000448032
ENST00000546925 ENSP00000448620
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008486 diphosphoinositol-polyphosphate diphosphatase activity
GO:0016787 hydrolase activity
GO:0030515 snoRNA binding
GO:0046872 metal ion binding
GO:0052840 inositol diphosphate tetrakisphosphate diphosphatase activity
GO:0052843 inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity
GO:0052844 inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity
GO:0052845 inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity
GO:0052846 inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity
GO:0052847 inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity
GO:0052848 inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity
Biological Process
GO:0008152 metabolic process
GO:0009187 cyclic nucleotide metabolic process
GO:0019722 calcium-mediated signaling
GO:0019935 cyclic-nucleotide-mediated signaling
GO:0035556 intracellular signal transduction
GO:0043647 inositol phosphate metabolic process
GO:0044281 small molecule metabolic process
GO:0046831 regulation of RNA export from nucleus
GO:0046907 intracellular transport
Cellular Component
GO:0005622 intracellular
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000020029
View Gene Order
Pathways
NETPATH
REACTOME
REACT_150188
Synthesis of pyrophosphates in the cytosol pathway
REACT_150154
Inositol phosphate metabolism pathway
REACT_111217
Metabolism pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.506325 Hs.601274 Hs.604140 Hs.629087 Hs.638185 Hs.735514
RefSeq NM_001301022 NM_001301023 NM_001301024 NM_019094 NM_199040 XM_005268595
HUGO
OMIM
CCDS CCDS44952 CCDS73504 CCDS9044
HPRD 14850
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca