Version 5.4
Homo sapiens Protein: ORC4
Summary
InnateDB Protein IDBP-589052.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ORC4
Protein Name origin recognition complex, subunit 4
Synonyms ORC4L; ORC4P;
Species Homo sapiens
Ensembl Protein ENSP00000438326
InnateDB Gene IDBG-71780 (ORC4)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
Experimentally validated
Total 39 [view]
Protein-Protein 37 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003677 DNA binding
GO:0003688 DNA replication origin binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0017111 nucleoside-triphosphatase activity
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
GO:0006260 DNA replication
GO:0006270 DNA replication initiation
Cellular Component
GO:0000808 origin recognition complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005664 nuclear origin of replication recognition complex
Protein Structure and Domains
PDB ID
InterPro IPR003959 ATPase, AAA-type, core
IPR016527 Origin recognition complex, subunit 4
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF00004
PF07724
PF13304
PRINTS
PIRSF PIRSF007858
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O43929
PhosphoSite PhosphoSite-O43929
TrEMBL Q96B14
UniProt Splice Variant
Entrez Gene 5000
UniGene Hs.558364
RefSeq NP_001177811
HUGO HGNC:8490
OMIM 603056
CCDS CCDS54405
HPRD 09118
IMGT
EMBL AC009480 AC019226 AF022108 AF047598 AF132596 AK295721 AK298862 AK299749 AY600302 BC014847 BC016177 CH471058
GenPept AAC01957 AAC80282 AAD22110 AAH14847 AAH16177 AAS94326 AAX93051 BAH12166 BAH12887 BAH13118 EAX11555 EAX11556 EAX11557 EAX11558 EAX11560

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca