InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SIPA1

Summary

InnateDB Protein

IDBP-589055.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SIPA1

Protein Name

signal-induced proliferation-associated 1

Synonyms

SPA1;

Species

Homo sapiens

Ensembl Protein

ENSP00000436269

InnateDB Gene

IDBG-242018 (SIPA1)

Protein Structure

UniProt Annotation

Function

GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting it to the putatively inactive GDP-bound state. {ECO:0000269PubMed:9346962}.

Subcellular Localization

Nucleus. Cytoplasm, perinuclear region. Endomembrane system; Peripheral membrane protein. Note=Mostly localized in the perinuclear membraneous region.

Disease Associations

Tissue Specificity

Expressed in fetal as well as in adult tissues. Expressed abundantly in the lymphoid tissues such as thymus, spleen and peripheral blood lymphocytes and also shows a significant expression in the spinal cord.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005096	GTPase activator activity
GO:0005515	protein binding
GO:0046582	Rap GTPase activator activity

Biological Process

GO:0007010	cytoskeleton organization
GO:0007162	negative regulation of cell adhesion
GO:0007165	signal transduction
GO:0008283	cell proliferation
GO:0030308	negative regulation of cell growth
GO:0032854	positive regulation of Rap GTPase activity
GO:0035556	intracellular signal transduction
GO:0043547	positive regulation of GTPase activity
GO:0045786	negative regulation of cell cycle
GO:0051056	regulation of small GTPase mediated signal transduction