Homo sapiens Gene: SIPA1
Summary
InnateDB Gene IDBG-242018.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SIPA1
Gene Name signal-induced proliferation-associated 1
Synonyms SPA1;
Species Homo sapiens
Ensembl Gene ENSG00000213445
Encoded Proteins
signal-induced proliferation-associated 1
signal-induced proliferation-associated 1
signal-induced proliferation-associated 1
signal-induced proliferation-associated 1
signal-induced proliferation-associated 1
signal-induced proliferation-associated 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The product of this gene is a mitogen induced GTPase activating protein (GAP). It exhibits a specific GAP activity for Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or other small GTPases. This protein may also hamper mitogen-induced cell cycle progression when abnormally or prematurely expressed. It is localized to the perinuclear region. Two alternatively spliced variants encoding the same isoform have been characterized to date. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:65585395-65650930
Strand Forward strand
Band q13.1
Transcripts
ENST00000394227 ENSP00000377774
ENST00000394224 ENSP00000377771
ENST00000534313 ENSP00000436269
ENST00000533361 ENSP00000436683
ENST00000526137 ENSP00000434362
ENST00000527525 ENSP00000433686
ENST00000534406
ENST00000530226
ENST00000531339
ENST00000529725
ENST00000528699
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005096 GTPase activator activity
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
GO:0046582 Rap GTPase activator activity
Biological Process
GO:0007010 cytoskeleton organization
GO:0007162 negative regulation of cell adhesion
GO:0007165 signal transduction
GO:0008283 cell proliferation
GO:0030308 negative regulation of cell growth
GO:0032854 positive regulation of Rap GTPase activity
GO:0035556 intracellular signal transduction
GO:0042631 cellular response to water deprivation
GO:0043547 positive regulation of GTPase activity
GO:0045786 negative regulation of cell cycle
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
GO:0016020 membrane
GO:0030133 transport vesicle
GO:0043234 protein complex
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Rap1 signalling pathway
Adaptive Immune System pathway
Immune System pathway
KEGG
Leukocyte transendothelial migration pathway
INOH
PID BIOCARTA
PID NCI
PDGFR-beta signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.530477
RefSeq NM_006747 NM_153253 XM_005274189
HUGO
OMIM
CCDS CCDS8108
HPRD 03713
IMGT
EMBL
GenPept
RNA Seq Atlas