InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SIPA1

Summary

InnateDB Gene

IDBG-242018.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SIPA1

Gene Name

signal-induced proliferation-associated 1

Synonyms

SPA1

Species

Homo sapiens

Ensembl Gene

ENSG00000213445

Encoded Proteins

IDBP-242020

signal-induced proliferation-associated 1

IDBP-242022

signal-induced proliferation-associated 1

IDBP-589055

signal-induced proliferation-associated 1

IDBP-592309

signal-induced proliferation-associated 1

IDBP-599894

signal-induced proliferation-associated 1

IDBP-593756

signal-induced proliferation-associated 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The product of this gene is a mitogen induced GTPase activating protein (GAP). It exhibits a specific GAP activity for Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or other small GTPases. This protein may also hamper mitogen-induced cell cycle progression when abnormally or prematurely expressed. It is localized to the perinuclear region. Two alternatively spliced variants encoding the same isoform have been characterized to date. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:65585395-65650930

Strand

Forward strand

Band

q13.1

Transcripts

ENST00000394227	ENSP00000377774
ENST00000394224	ENSP00000377771
ENST00000534313	ENSP00000436269
ENST00000533361	ENSP00000436683
ENST00000526137	ENSP00000434362
ENST00000527525	ENSP00000433686
ENST00000534406
ENST00000530226
ENST00000531339
ENST00000529725
ENST00000528699

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005096	GTPase activator activity
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0046582	Rap GTPase activator activity

Biological Process

GO:0007010	cytoskeleton organization
GO:0007162	negative regulation of cell adhesion
GO:0007165	signal transduction
GO:0008283	cell proliferation
GO:0030308	negative regulation of cell growth
GO:0032854	positive regulation of Rap GTPase activity
GO:0035556	intracellular signal transduction
GO:0042631	cellular response to water deprivation
GO:0043547	positive regulation of GTPase activity
GO:0045786	negative regulation of cell cycle
GO:0051056	regulation of small GTPase mediated signal transduction
GO:0051726	regulation of cell cycle

Cellular Component

GO:0005634	nucleus
GO:0005829	cytosol
GO:0016020	membrane
GO:0030133	transport vesicle
GO:0043234	protein complex
GO:0048471	perinuclear region of cytoplasm

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000056917

View Gene Order

ENSBTAG00000013884

Not yet available

Pathways

NETPATH

REACTOME

REACT_23898

Rap1 signalling pathway

REACT_75774

Adaptive Immune System pathway

REACT_6900

Immune System pathway

KEGG

hsa04670

Leukocyte transendothelial migration pathway

INOH

PID NCI

pdgfrbpathway

PDGFR-beta signaling pathway

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.530477

RefSeq

NM_006747 NM_153253 XM_005274189

HUGO

OMIM

CCDS

CCDS8108

HPRD

03713

IMGT

EMBL

GenPept

RNA Seq Atlas