InnateDB Protein
|
IDBP-589121.2
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
MITF
|
Protein Name
|
microphthalmia-associated transcription factor
|
Synonyms
|
bHLHe32; CMM8; MI; WS2; WS2A;
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000435909
|
InnateDB Gene
|
IDBG-44086 (MITF)
|
Protein Structure
|
|
Function |
|
Subcellular Localization |
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated |
Total |
39
[view]
|
Protein-Protein |
30
[view]
|
Protein-DNA |
7
[view]
|
Protein-RNA |
0
|
DNA-DNA |
2
[view]
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
11 [view]
|
|
|
Molecular Function |
Accession |
GO Term |
GO:0000978
|
RNA polymerase II core promoter proximal region sequence-specific DNA binding
|
GO:0001077
|
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
|
GO:0005515
|
protein binding
|
GO:0046983
|
protein dimerization activity
|
|
Biological Process |
GO:0006355
|
regulation of transcription, DNA-templated
|
GO:0006461
|
protein complex assembly
|
GO:0030318
|
melanocyte differentiation
|
GO:0045893
|
positive regulation of transcription, DNA-templated
|
GO:0045944
|
positive regulation of transcription from RNA polymerase II promoter
|
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR011598
Myc-type, basic helix-loop-helix (bHLH) domain
IPR021802
Basic helix-loop-helix leucine zipper transcrition factor MiT/TFE
|
PFAM |
PF00010
PF11851
|
PRINTS |
|
PIRSF |
|
SMART |
SM00353
|
TIGRFAMs |
|
Modification |
|
SwissProt |
O75030
|
PhosphoSite |
PhosphoSite-O75030
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
4286
|
UniGene |
Hs.712759
|
RefSeq |
NP_937821
|
HUGO |
HGNC:7105
|
OMIM |
156845
|
CCDS |
CCDS46866
|
HPRD |
01138
|
IMGT |
|
EMBL |
AB006909
AB006989
AB009608
AB032357
AB032358
AB032359
AC099326
AC104445
AC104449
AC124915
AF034755
AK296129
AL110195
BC026961
BC065243
GU355676
Z29678
|
GenPept |
AAC39639
AAH26961
AAH65243
ADB90411
BAA32288
BAA95206
BAA95207
BAA95208
BAA95209
BAG58874
CAA82775
CAB53672
|
|
|