InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TGOLN2

Summary

InnateDB Protein

IDBP-58922.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TGOLN2

Protein Name

trans-golgi network protein 2

Synonyms

TGN38; TGN46; TGN48; TGN51; TTGN2;

Species

Homo sapiens

Ensembl Protein

ENSP00000366603

InnateDB Gene

IDBG-58918 (TGOLN2)

Protein Structure

UniProt Annotation

Function

May be involved in regulating membrane traffic to and from trans-Golgi network.

Subcellular Localization

Cell membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single- pass type I membrane protein. Note=Primarily in trans-Golgi network. Cycles between the trans-Golgi network and the cell surface returning via endosomes.

Disease Associations

Tissue Specificity

Isoform TGN46 is widely expressed. Isoform TGN51 is more abundant in fetal lung and kidney. Isoform TGN48 is barely expressed in embryonic kidney and promyelocytic cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.

Experimentally validated
Total	17 [view]
Protein-Protein	16 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

Cellular Component

GO:0005634	nucleus
GO:0005794	Golgi apparatus
GO:0005802	trans-Golgi network
GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0030133	transport vesicle