Version 5.4
Homo sapiens Protein: RGS5
Summary
InnateDB Protein IDBP-590606.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RGS5
Protein Name regulator of G-protein signaling 5
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000432313
InnateDB Gene IDBG-104435 (RGS5)
Protein Structure
UniProt Annotation
Function Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha (By similarity). {ECO:0000250}.
Subcellular Localization Isoform 1: Cytoplasm. Membrane.Isoform 2: Cytoplasm.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005096 GTPase activator activity
Biological Process
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway
GO:0038032 termination of G-protein coupled receptor signaling pathway
GO:0043547 positive regulation of GTPase activity
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
Protein Structure and Domains
PDB ID
InterPro IPR000342 Regulator of G protein signalling domain
IPR016137 Regulator of G protein signalling superfamily
PFAM PF00615
PRINTS PR01301
PIRSF
SMART SM00315
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O15539
PhosphoSite PhosphoSite-O15539
TrEMBL
UniProt Splice Variant
Entrez Gene 8490
UniGene Hs.701237
RefSeq NP_001182232
HUGO HGNC:10001
OMIM 603276
CCDS CCDS55652
HPRD 04471
IMGT
EMBL AB008109 AF030108 AF159570 AF493929 AJ891044 AL451063 AL499616 AL583850 BC030059 BU172751 BX537427 CH471067
GenPept AAB84001 AAD40957 AAH30059 AAM12643 BAA22889 CAD97669 CAH71851 CAH73764 CAI15095 CAI76926 EAW90731

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca