Version 5.4
Homo sapiens Gene: RGS5
Summary
InnateDB Gene IDBG-104435.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RGS5
Gene Name regulator of G-protein signaling 5
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000143248
Encoded Proteins
IDBP-104437
regulator of G-protein signaling 5
IDBP-104441
regulator of G-protein signaling 5
IDBP-600275
regulator of G-protein signaling 5
IDBP-590606
regulator of G-protein signaling 5
IDBP-599340
regulator of G-protein signaling 5
IDBP-813258
regulator of G-protein signaling 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the regulators of G protein signaling (RGS) family. The RGS proteins are signal transduction molecules which are involved in the regulation of heterotrimeric G proteins by acting as GTPase activators. This gene is a hypoxia-inducible factor-1 dependent, hypoxia-induced gene which is involved in the induction of endothelial apoptosis. This gene is also one of three genes on chromosome 1q contributing to elevated blood pressure. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Dec 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:163111121-163321791
Strand Reverse strand
Band q23.3
Transcripts
ENST00000313961 ENSP00000319308
ENST00000367903 ENSP00000356879
ENST00000469495
ENST00000530507 ENSP00000433001
ENST00000527988 ENSP00000432313
ENST00000525894
ENST00000531476 ENSP00000435861
ENST00000618415 ENSP00000480891
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005096 GTPase activator activity
Biological Process
GO:0007165 signal transduction
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway
GO:0038032 termination of G-protein coupled receptor signaling pathway
GO:0043547 positive regulation of GTPase activity
GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026678
View Gene Order
ENSBTAG00000016341
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
INOH website
GPCR signaling pathway
PID NCI
Cross-References
SwissProt
TrEMBL E9PS96
UniProt Splice Variant
Entrez Gene 8490
UniGene Hs.24950 Hs.623400 Hs.701237
RefSeq NM_001195303 NM_001254748 NM_001254749 NM_003617
HUGO HGNC:10001
OMIM 603276
CCDS CCDS1244 CCDS55652 CCDS58041
HPRD 04471
IMGT
EMBL AL451063 AL499616 AL583850 AL592435
GenPept
RNA Seq Atlas 8490

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca