InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TJP2

Summary

InnateDB Protein

IDBP-590806.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TJP2

Protein Name

tight junction protein 2 (zona occludens 2)

Synonyms

C9DUPq21.11; DFNA51; DUP9q21.11; PFIC4; X104; ZO2;

Species

Homo sapiens

Ensembl Protein

ENSP00000438262

InnateDB Gene

IDBG-69307 (TJP2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 51 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	51 [view]
Protein-Protein	51 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004385	guanylate kinase activity
GO:0005515	protein binding
GO:0008022	protein C-terminus binding

Biological Process

GO:0006915	apoptotic process
GO:0006921	cellular component disassembly involved in execution phase of apoptosis
GO:0010033	response to organic substance
GO:0035329	hippo signaling
GO:0046939	nucleotide phosphorylation

Cellular Component

GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005912	adherens junction
GO:0005923	tight junction
GO:0030054	cell junction

Protein Structure and Domains

PDB ID

InterPro

IPR001452 SH3 domain
IPR001478 PDZ domain
IPR005417 Zona occludens protein
IPR005419 Zona occludens protein ZO-2
IPR008144 Guanylate kinase-like
IPR008145 Guanylate kinase/L-type calcium channel beta subunit
IPR011511 Variant SH3 domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00018
PF14604
PF00595
PF13180
PF00625
PF07653

PRINTS

PR00452
PR01597
PR01599

PIRSF

SMART

SM00326
SM00228
SM00072

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt