Version 5.4
Homo sapiens Protein: DCAF12
Summary
InnateDB Protein IDBP-59131.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DCAF12
Protein Name DDB1 and CUL4 associated factor 12
Synonyms CT102; KIAA1892; TCC52; WDR40A;
Species Homo sapiens
Ensembl Protein ENSP00000355114
InnateDB Gene IDBG-59129 (DCAF12)
Protein Structure
UniProt Annotation
Function May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. {ECO:0000269PubMed:16949367, ECO:0000269PubMed:16964240}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:18957058}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269PubMed:18957058}.
Disease Associations
Tissue Specificity Highly expressed in lung cancer tissues and some cancer cell lines. Restricted expression in normal testis. {ECO:0000269PubMed:18957058}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0016567 protein ubiquitination
Cellular Component
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0080008 Cul4-RING E3 ubiquitin ligase complex
Protein Structure and Domains
PDB ID
InterPro IPR001680 WD40 repeat
IPR017986 WD40-repeat-containing domain
PFAM PF00400
PRINTS
PIRSF
SMART SM00320
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5T6F0
PhosphoSite PhosphoSite-Q5T6F0
TrEMBL
UniProt Splice Variant
Entrez Gene 25853
UniGene Hs.741270
RefSeq NP_056212
HUGO HGNC:19911
OMIM
CCDS CCDS6549
HPRD 10031
IMGT
EMBL AB067479 AK000354 AK292935 AL117646 AL354989 BC008893 BC063823 CH471071 DQ518909
GenPept AAH08893 AAH63823 ABG24246 BAA91106 BAB67785 BAF85624 CAB56028 CAI15300 CAI15301 CAI15302 EAW58472 EAW58473

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca