InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MAT2A

Summary

InnateDB Protein

IDBP-59134.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAT2A

Protein Name

methionine adenosyltransferase II, alpha

Synonyms

MATA2; MATII; SAMS2;

Species

Homo sapiens

Ensembl Protein

ENSP00000303147

InnateDB Gene

IDBG-59132 (MAT2A)

Protein Structure

UniProt Annotation

Function

Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	27 [view]
Protein-Protein	23 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004478	methionine adenosyltransferase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0046872	metal ion binding

Biological Process

GO:0000096	sulfur amino acid metabolic process
GO:0006556	S-adenosylmethionine biosynthetic process
GO:0006730	one-carbon metabolic process
GO:0006805	xenobiotic metabolic process
GO:0032259	methylation
GO:0034641	cellular nitrogen compound metabolic process
GO:0044281	small molecule metabolic process

Cellular Component

GO:0005829	cytosol
GO:0048269	methionine adenosyltransferase complex

Protein Structure and Domains

PDB ID

InterPro

IPR002133 S-adenosylmethionine synthetase
IPR022628 S-adenosylmethionine synthetase, N-terminal
IPR022629 S-adenosylmethionine synthetase, central domain
IPR022630 S-adenosylmethionine synthetase, C-terminal
IPR022636 S-adenosylmethionine synthetase superfamily

PFAM

PF00438
PF02772
PF02773

PRINTS

PIRSF

PIRSF000497

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P31153