Version 5.4
Homo sapiens Protein: FGD6
Summary
InnateDB Protein IDBP-591373.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FGD6
Protein Name FYVE, RhoGEF and PH domain containing 6
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000450342
InnateDB Gene IDBG-51604 (FGD6)
Protein Structure
UniProt Annotation
Function May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating the actin cytoskeleton and cell shape (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000305}. Cytoplasm, cytoskeleton {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0031267 small GTPase binding
GO:0046872 metal ion binding
Biological Process
GO:0007010 cytoskeleton organization
GO:0008360 regulation of cell shape
GO:0030036 actin cytoskeleton organization
GO:0032321 positive regulation of Rho GTPase activity
GO:0035023 regulation of Rho protein signal transduction
GO:0043088 regulation of Cdc42 GTPase activity
GO:0043547 positive regulation of GTPase activity
GO:0046847 filopodium assembly
Cellular Component
GO:0001726 ruffle
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005856 cytoskeleton
GO:0030027 lamellipodium
Protein Structure and Domains
PDB ID
InterPro IPR000219 Dbl homology (DH) domain
IPR000306 FYVE zinc finger
IPR001849 Pleckstrin homology domain
IPR011011 Zinc finger, FYVE/PHD-type
IPR017455 Zinc finger, FYVE-related
PFAM PF00621
PF01363
PF00169
PRINTS
PIRSF
SMART SM00325
SM00064
SM00233
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6ZV73
PhosphoSite PhosphoSite-Q6ZV73
TrEMBL F8VY01
UniProt Splice Variant
Entrez Gene 55785
UniGene Hs.707232
RefSeq XP_005269081
HUGO HGNC:21740
OMIM 613520
CCDS
HPRD 16892
IMGT
EMBL AB037783 AC011598 AC126615 AC127165 AK002045 AK124904 AK128492 BC013319 BX538322
GenPept AAH13319 BAA92052 BAA92600 BAC85990 BAC87464 CAD98096

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca