InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HTR2A

Summary

InnateDB Protein

IDBP-591467.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HTR2A

Protein Name

5-hydroxytryptamine (serotonin) receptor 2A

Synonyms

5-HT2A; HTR2;

Species

Homo sapiens

Ensembl Protein

ENSP00000437737

InnateDB Gene

IDBG-31141 (HTR2A)

Protein Structure

UniProt Annotation

Function

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5- dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca(2+) ions from intracellular stores. Affects neural activity, perception, cognition and mood. Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction. {ECO:0000269PubMed:1330647, ECO:0000269PubMed:18297054, ECO:0000269PubMed:18703043, ECO:0000269PubMed:19057895, ECO:0000269PubMed:21645528, ECO:0000269PubMed:22300836}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein. Cell projection, dendrite {ECO:0000250}. Cell projection, axon {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Membrane, caveola {ECO:0000250}. Note=Localizes to the postsynaptic thickening of axo-dendritic synapses. {ECO:0000250}.

Disease Associations

Tissue Specificity

Detected in brain cortex (at protein level). Detected in blood platelets. {ECO:0000269PubMed:18297054}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001965	G-protein alpha-subunit binding
GO:0004930	G-protein coupled receptor activity
GO:0004993	serotonin receptor activity
GO:0005515	protein binding
GO:0008144	drug binding
GO:0032403	protein complex binding
GO:0051378	serotonin binding
GO:0071886	1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding

Biological Process

GO:0001659	temperature homeostasis
GO:0006874	cellular calcium ion homeostasis
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007202	activation of phospholipase C activity
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007208	phospholipase C-activating serotonin receptor signaling pathway
GO:0007210	serotonin receptor signaling pathway
GO:0007268	synaptic transmission
GO:0007568	aging
GO:0007613	memory
GO:0008219	cell death
GO:0008284	positive regulation of cell proliferation
GO:0010513	positive regulation of phosphatidylinositol biosynthetic process
GO:0014059	regulation of dopamine secretion
GO:0014065	phosphatidylinositol 3-kinase signaling
GO:0014824	artery smooth muscle contraction
GO:0014832	urinary bladder smooth muscle contraction
GO:0019233	sensory perception of pain
GO:0030431	sleep
GO:0033674	positive regulation of kinase activity
GO:0042493	response to drug
GO:0043267	negative regulation of potassium ion transport
GO:0043406	positive regulation of MAP kinase activity
GO:0044380	protein localization to cytoskeleton
GO:0045821	positive regulation of glycolytic process
GO:0045907	positive regulation of vasoconstriction
GO:0046883	regulation of hormone secretion
GO:0048148	behavioral response to cocaine
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0050795	regulation of behavior
GO:0050965	detection of temperature stimulus involved in sensory perception of pain
GO:0050966	detection of mechanical stimulus involved in sensory perception of pain
GO:0051209	release of sequestered calcium ion into cytosol
GO:0051967	negative regulation of synaptic transmission, glutamatergic
GO:0070374	positive regulation of ERK1 and ERK2 cascade

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005901	caveola
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0030424	axon
GO:0030425	dendrite
GO:0043025	neuronal cell body
GO:0043198	dendritic shaft
GO:0070852	cell body fiber

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000455 5-Hydroxytryptamine 2A receptor
IPR002231 5-hydroxytryptamine receptor family
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx

PFAM

PF00001
PF10320

PRINTS

PR00237
PR00516
PR01101

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P28223