Version 5.4
Homo sapiens Gene: HTR2A
Summary
InnateDB Gene IDBG-31141.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HTR2A
Gene Name 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
Synonyms 5-HT2A; HTR2
Species Homo sapiens
Ensembl Gene ENSG00000102468
Encoded Proteins
IDBP-31143
5-hydroxytryptamine (serotonin) receptor 2A
IDBP-588596
5-hydroxytryptamine (serotonin) receptor 2A
IDBP-591467
5-hydroxytryptamine (serotonin) receptor 2A
IDBP-812550
5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes one of the receptors for serotonin, a neurotransmitter with many roles. Mutations in this gene are associated with susceptibility to schizophrenia and obsessive-compulsive disorder, and are also associated with response to the antidepressant citalopram in patients with major depressive disorder (MDD). MDD patients who also have a mutation in intron 2 of this gene show a significantly reduced response to citalopram as this antidepressant downregulates expression of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:46831550-46897076
Strand Reverse strand
Band q14.2
Transcripts
ENST00000378688 ENSP00000367959
ENST00000543956 ENSP00000441861
ENST00000542664 ENSP00000437737
ENST00000612998 ENSP00000482708
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001965 G-protein alpha-subunit binding
GO:0004930 G-protein coupled receptor activity
GO:0004993 serotonin receptor activity
GO:0005515 protein binding
GO:0008144 drug binding
GO:0032403 protein complex binding
GO:0051378 serotonin binding
GO:0071886 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding
Biological Process
GO:0001659 temperature homeostasis
GO:0006874 cellular calcium ion homeostasis
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007202 activation of phospholipase C activity
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007208 phospholipase C-activating serotonin receptor signaling pathway
GO:0007210 serotonin receptor signaling pathway
GO:0007268 synaptic transmission
GO:0007568 aging
GO:0007613 memory
GO:0008219 cell death
GO:0008284 positive regulation of cell proliferation
GO:0010513 positive regulation of phosphatidylinositol biosynthetic process
GO:0014059 regulation of dopamine secretion
GO:0014065 phosphatidylinositol 3-kinase signaling
GO:0014824 artery smooth muscle contraction
GO:0014832 urinary bladder smooth muscle contraction
GO:0019233 sensory perception of pain
GO:0030431 sleep
GO:0033674 positive regulation of kinase activity
GO:0042493 response to drug
GO:0043267 negative regulation of potassium ion transport
GO:0043406 positive regulation of MAP kinase activity
GO:0044380 protein localization to cytoskeleton
GO:0045821 positive regulation of glycolytic process
GO:0045907 positive regulation of vasoconstriction
GO:0046883 regulation of hormone secretion
GO:0048148 behavioral response to cocaine
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050795 regulation of behavior
GO:0050965 detection of temperature stimulus involved in sensory perception of pain
GO:0050966 detection of mechanical stimulus involved in sensory perception of pain
GO:0051209 release of sequestered calcium ion into cytosol
GO:0051967 negative regulation of synaptic transmission, glutamatergic
GO:0070374 positive regulation of ERK1 and ERK2 cascade
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005901 caveola
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016023 cytoplasmic membrane-bounded vesicle
GO:0030424 axon
GO:0030425 dendrite
GO:0043025 neuronal cell body
GO:0043198 dendritic shaft
GO:0070852 cell body fiber
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000034997
View Gene Order
ENSBTAG00000013498
Not yet available
Pathways
NETPATH
REACTOME
REACT_18283
G alpha (q) signalling events pathway
REACT_120966
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_17064
Serotonin receptors pathway
REACT_16983
Amine ligand-binding receptors pathway
REACT_14828
Class A/1 (Rhodopsin-like receptors) pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_21340
GPCR ligand binding pathway
KEGG
hsa04080
Neuroactive ligand-receptor interaction pathway
hsa04540
Gap junction pathway
hsa04020
Calcium signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.72630
RefSeq NM_000621 NM_001165947
HUGO
OMIM
CCDS CCDS53867 CCDS9405
HPRD 01638
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca