InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SRP54

Summary

InnateDB Protein

IDBP-591532.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SRP54

Protein Name

signal recognition particle 54kDa

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000451818

InnateDB Gene

IDBG-4659 (SRP54)

Protein Structure

UniProt Annotation

Function

Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein).

Subcellular Localization

Nucleus speckle {ECO:0000269PubMed:14729963}. Cytoplasm {ECO:0000269PubMed:14729963}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.

Experimentally validated
Total	29 [view]
Protein-Protein	26 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005525	GTP binding
GO:0008144	drug binding
GO:0008312	7S RNA binding
GO:0019003	GDP binding
GO:0030942	endoplasmic reticulum signal peptide binding
GO:0043021	ribonucleoprotein complex binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006184	GTP catabolic process
GO:0006412	translation
GO:0006614	SRP-dependent cotranslational protein targeting to membrane
GO:0006616	SRP-dependent cotranslational protein targeting to membrane, translocation
GO:0006617	SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition
GO:0010467	gene expression
GO:0042493	response to drug
GO:0044267	cellular protein metabolic process
GO:0045047	protein targeting to ER

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005786	signal recognition particle, endoplasmic reticulum targeting
GO:0005829	cytosol
GO:0016607	nuclear speck
GO:0048500	signal recognition particle

Protein Structure and Domains

PDB ID

InterPro

IPR000897 Signal recognition particle, SRP54 subunit, GTPase domain
IPR002586 CobQ/CobB/MinD/ParA nucleotide binding domain
IPR003495 CobW/HypB/UreG domain
IPR003593 AAA+ ATPase domain
IPR004125 Signal recognition particle, SRP54 subunit, M-domain
IPR006325 Signal recognition particle, SRP54 subunit, eukaryotic
IPR013822 Signal recognition particle, SRP54 subunit, helical bundle
IPR027417 P-loop containing nucleoside triphosphate hydrolase
IPR029007 MobB-type P-loop domain

PFAM

PF00448
PF01656
PF02492
PF02978
PF02881
PF03205

PRINTS

PIRSF

SMART

SM00962
SM00382
SM00963

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P61011