InnateDB Protein
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IDBP-591600.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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FRS2
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Protein Name
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fibroblast growth factor receptor substrate 2
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Synonyms
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FRS2A; FRS2alpha; SNT; SNT-1; SNT1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000447241
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InnateDB Gene
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IDBG-47144 (FRS2)
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Protein Structure
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Function |
Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3- kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1. {ECO:0000269PubMed:12974390, ECO:0000269PubMed:21765395}.
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Subcellular Localization |
Endomembrane system. Note=Cytoplasmic, membrane-bound.
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Disease Associations |
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Tissue Specificity |
Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis. {ECO:0000269PubMed:10092678}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated |
Total |
25
[view]
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Protein-Protein |
25
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
7 [view]
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Molecular Function |
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Biological Process |
GO:0000186
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activation of MAPKK activity
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GO:0000187
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activation of MAPK activity
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GO:0001702
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gastrulation with mouth forming second
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GO:0001759
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organ induction
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GO:0002088
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lens development in camera-type eye
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GO:0003281
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ventricular septum development
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GO:0007169
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transmembrane receptor protein tyrosine kinase signaling pathway
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GO:0007173
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epidermal growth factor receptor signaling pathway
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GO:0007185
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transmembrane receptor protein tyrosine phosphatase signaling pathway
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GO:0007186
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G-protein coupled receptor signaling pathway
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GO:0007405
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neuroblast proliferation
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GO:0008286
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insulin receptor signaling pathway
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GO:0008543
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fibroblast growth factor receptor signaling pathway
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GO:0008595
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anterior/posterior axis specification, embryo
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GO:0030900
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forebrain development
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GO:0038095
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Fc-epsilon receptor signaling pathway
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GO:0042981
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regulation of apoptotic process
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GO:0045087
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innate immune response
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GO:0046619
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optic placode formation involved in camera-type eye formation
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GO:0048011
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neurotrophin TRK receptor signaling pathway
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GO:0048015
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phosphatidylinositol-mediated signaling
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GO:0050678
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regulation of epithelial cell proliferation
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GO:0060527
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prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
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GO:0070307
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lens fiber cell development
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GO:0070372
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regulation of ERK1 and ERK2 cascade
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Cellular Component |
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PDB ID |
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InterPro |
IPR002404
Insulin receptor substrate-1, PTB
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PFAM |
PF02174
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PRINTS |
PR00628
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PIRSF |
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SMART |
SM00310
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TIGRFAMs |
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Modification |
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SwissProt |
Q8WU20
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PhosphoSite |
PhosphoSite-Q8WU20
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TrEMBL |
L7RTG7
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UniProt Splice Variant |
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Entrez Gene |
10818
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UniGene |
Hs.609298
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RefSeq |
NP_001265286
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HUGO |
HGNC:16971
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OMIM |
607743
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CCDS |
CCDS41809
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HPRD |
06372
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IMGT |
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EMBL |
AC018921
AF036717
AK312477
BC021562
CH471054
EU332842
JX512443
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GenPept |
AAB92554
AAH21562
ABY87531
AGC09590
BAG35381
EAW97225
EAW97226
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