Homo sapiens Gene: FRS2
InnateDB Gene IDBG-47144.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FRS2
Gene Name fibroblast growth factor receptor substrate 2
Synonyms FRS2A; FRS2alpha; SNT; SNT-1; SNT1
Species Homo sapiens
Ensembl Gene ENSG00000166225
Encoded Proteins
fibroblast growth factor receptor substrate 2
fibroblast growth factor receptor substrate 2
fibroblast growth factor receptor substrate 2
fibroblast growth factor receptor substrate 2
fibroblast growth factor receptor substrate 2
fibroblast growth factor receptor substrate 2
fibroblast growth factor receptor substrate 2
fibroblast growth factor receptor substrate 2
fibroblast growth factor receptor substrate 2
fibroblast growth factor receptor substrate 2
fibroblast growth factor receptor substrate 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 12:69470349-69579789
Strand Forward strand
Band q15
ENST00000397997 ENSP00000381083
ENST00000547219 ENSP00000447724
ENST00000549921 ENSP00000450048
ENST00000550316 ENSP00000450000
ENST00000548154 ENSP00000449105
ENST00000547414 ENSP00000447007
ENST00000550389 ENSP00000447241
ENST00000550937 ENSP00000447804
ENST00000549092 ENSP00000449111
ENST00000550169 ENSP00000447978
ENST00000551325 ENSP00000449432
Number of Interactions This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 25 [view]
Protein-Protein 25 [view]
Protein-DNA 0
Protein-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity
GO:0005104 fibroblast growth factor receptor binding
GO:0005158 insulin receptor binding
GO:0005168 neurotrophin TRKA receptor binding
GO:0005515 protein binding
GO:0019211 phosphatase activator activity
Biological Process
GO:0000186 activation of MAPKK activity
GO:0000187 activation of MAPK activity
GO:0001702 gastrulation with mouth forming second
GO:0001759 organ induction
GO:0002088 lens development in camera-type eye
GO:0003281 ventricular septum development
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007405 neuroblast proliferation
GO:0008286 insulin receptor signaling pathway
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0008595 anterior/posterior axis specification, embryo
GO:0030900 forebrain development
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0042981 regulation of apoptotic process
GO:0045087 innate immune response
GO:0046619 optic placode formation involved in camera-type eye formation
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0050678 regulation of epithelial cell proliferation
GO:0060527 prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:0070307 lens fiber cell development
GO:0070372 regulation of ERK1 and ERK2 cascade
Cellular Component
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005911 cell-cell junction
GO:0016020 membrane
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
EGFR1 pathway
PIP3 activates AKT signaling pathway
DAP12 signaling pathway
DAP12 interactions pathway
PI3K/AKT activation pathway
Frs2-mediated activation pathway
GAB1 signalosome pathway
Signaling by EGFR pathway
PI3K events in ERBB4 signaling pathway
Signaling by ERBB4 pathway
PI3K Cascade pathway
Signaling by Insulin receptor pathway
IRS-related events triggered by IGF1R pathway
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
PI3K events in ERBB2 signaling pathway
Signaling by ERBB2 pathway
Negative regulation of FGFR signaling pathway
PI-3K cascade pathway
FRS2-mediated cascade pathway
Signaling by FGFR pathway
Signaling by SCF-KIT pathway
Downstream signal transduction pathway
Signaling by PDGF pathway
Signaling by FGFR mutants pathway
Constitutive PI3K/AKT Signaling in Cancer pathway
Signaling by FGFR in disease pathway
Signalling by NGF pathway
Signaling by EGFR in Cancer pathway
Downstream signaling of activated FGFR pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
Innate Immune System pathway
Fc epsilon receptor (FCERI) signaling pathway
Signal Transduction pathway
IRS-mediated signalling pathway
Adaptive Immune System pathway
Immune System pathway
Insulin receptor signalling cascade pathway
Signalling to ERKs pathway
NGF signalling via TRKA from the plasma membrane pathway
IRS-related events pathway
IGF1R signaling cascade pathway
Prolonged ERK activation events pathway
PI3K/AKT Signaling in Cancer pathway
Signaling by the B Cell Receptor (BCR) pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
Disease pathway
Neurotrophin signaling pathway pathway
FGF signaling pathway pathway
FGF signaling pathway
Signaling events regulated by Ret tyrosine kinase
SHP2 signaling
UniProt Splice Variant
Entrez Gene
UniGene Hs.593446 Hs.605393 Hs.609298
RefSeq NM_001042555 NM_001278351 NM_001278353 NM_001278354 NM_001278355 NM_001278356 NM_001278357 NM_006654
HPRD 06372
RNA Seq Atlas