InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: FRS2

Summary

InnateDB Gene

IDBG-47144.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FRS2

Gene Name

fibroblast growth factor receptor substrate 2

Synonyms

FRS2A; FRS2alpha; SNT; SNT-1; SNT1

Species

Homo sapiens

Ensembl Gene

ENSG00000166225

Encoded Proteins

IDBP-234116

fibroblast growth factor receptor substrate 2

IDBP-601714

fibroblast growth factor receptor substrate 2

IDBP-584719

fibroblast growth factor receptor substrate 2

IDBP-600752

fibroblast growth factor receptor substrate 2

IDBP-594788

fibroblast growth factor receptor substrate 2

IDBP-601642

fibroblast growth factor receptor substrate 2

IDBP-591600

fibroblast growth factor receptor substrate 2

IDBP-595780

fibroblast growth factor receptor substrate 2

IDBP-600994

fibroblast growth factor receptor substrate 2

IDBP-592673

fibroblast growth factor receptor substrate 2

IDBP-591436

fibroblast growth factor receptor substrate 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:69470349-69579789

Strand

Forward strand

Band

q15

Transcripts

ENST00000397997	ENSP00000381083
ENST00000547219	ENSP00000447724
ENST00000549921	ENSP00000450048
ENST00000550316	ENSP00000450000
ENST00000548154	ENSP00000449105
ENST00000547414	ENSP00000447007
ENST00000550389	ENSP00000447241
ENST00000550937	ENSP00000447804
ENST00000549092	ENSP00000449111
ENST00000550169	ENSP00000447978
ENST00000551325	ENSP00000449432

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	25 [view]
Protein-Protein	25 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity
GO:0005104	fibroblast growth factor receptor binding
GO:0005158	insulin receptor binding
GO:0005168	neurotrophin TRKA receptor binding
GO:0005515	protein binding
GO:0019211	phosphatase activator activity

Biological Process

GO:0000186	activation of MAPKK activity
GO:0000187	activation of MAPK activity
GO:0001702	gastrulation with mouth forming second
GO:0001759	organ induction
GO:0002088	lens development in camera-type eye
GO:0003281	ventricular septum development
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007185	transmembrane receptor protein tyrosine phosphatase signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007405	neuroblast proliferation
GO:0008286	insulin receptor signaling pathway
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0008595	anterior/posterior axis specification, embryo
GO:0030900	forebrain development
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0042981	regulation of apoptotic process
GO:0045087	innate immune response
GO:0046619	optic placode formation involved in camera-type eye formation
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048015	phosphatidylinositol-mediated signaling
GO:0050678	regulation of epithelial cell proliferation
GO:0060527	prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:0070307	lens fiber cell development
GO:0070372	regulation of ERK1 and ERK2 cascade

Cellular Component

GO:0005737	cytoplasm
GO:0005768	endosome
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005911	cell-cell junction
GO:0016020	membrane